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Abstract
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Understand some of the factors leading to "antibiotic anxiety". Appreciate the strengths and weaknesses of the 3 major approaches to determining duration of antimicrobial therapy in the literature. Envision a means by which different approaches can be combined to optimize future therapies.
Embedded in lecture slides.
Why intensivists are Confused On Appropriate Duration of Antibiotics. All 3 major methods of determining antibiotic duration have distinct strengths and weaknesses. 1) Fixed duration: limited by available trial data; clinical disconnect (i.e.: patient is better before duration finishes or worse after…); 2) Clinical criteria: symptoms linger past microbial “cure”; results in longer than necessary courses; 3) Biomarkers: conflicting data; may not shorten courses beyond fixed duration
Why intensivists are Confused On Appropriate Duration of Antibiotics. All 3 major methods of determining antibiotic duration have distinct strengths and weaknesses. 1) Fixed duration: limited by available trial data; clinical disconnect (i.e.: patient is better before duration finishes or worse after…); 2) Clinical criteria: symptoms linger past microbial “cure”; results in longer than necessary courses; 3) Biomarkers: conflicting data; may not shorten courses beyond fixed duration
Duration of Therapy
Dr. Nathan Nielsen
Dr. Nathan Nielsen
ESCMID eAcademy. Nielsen N. 02/27/2024; 409914; Disclosure(s): No disclosures relevant to this topic.
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Dr. Nathan Nielsen
Abstract
References
Discussion Forum (0)
Understand some of the factors leading to "antibiotic anxiety". Appreciate the strengths and weaknesses of the 3 major approaches to determining duration of antimicrobial therapy in the literature. Envision a means by which different approaches can be combined to optimize future therapies.
Embedded in lecture slides.
Why intensivists are Confused On Appropriate Duration of Antibiotics. All 3 major methods of determining antibiotic duration have distinct strengths and weaknesses. 1) Fixed duration: limited by available trial data; clinical disconnect (i.e.: patient is better before duration finishes or worse after…); 2) Clinical criteria: symptoms linger past microbial “cure”; results in longer than necessary courses; 3) Biomarkers: conflicting data; may not shorten courses beyond fixed duration
Why intensivists are Confused On Appropriate Duration of Antibiotics. All 3 major methods of determining antibiotic duration have distinct strengths and weaknesses. 1) Fixed duration: limited by available trial data; clinical disconnect (i.e.: patient is better before duration finishes or worse after…); 2) Clinical criteria: symptoms linger past microbial “cure”; results in longer than necessary courses; 3) Biomarkers: conflicting data; may not shorten courses beyond fixed duration

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