Session Type: 1-hour Oral Session
Session Title: 1-hour Oral Session
Authors(s): S. Bessis, L.M. Flora, K. Mahe, A. Djillali, G. L.d.l.g
Authors Affiliations(s): Hôpital Raymond-Poincaré, Aphp, France
Background:
Despite the emergence of SARS-Cov-2 responsible for Covid-19 since December 2019 in China, the tissue damage linked to SARS-Cov-2 is not yet well known. The aim of this work was therefore to determine the causes of death of patients infected with Covid-19 and to document anatomopathologically the lesions attributable to the SARS-Cov-2 virus on the various organs.
Case:Patients were autopsied in the Department of Pathological Anatomy and Forensic Medicine at the Raymond-Poincaré Hospital in compliance with the law on bioethics. Autopsies were performed according to Ghon's technique, and histological samples were taken from the following organs: heart, lungs, liver, kidneys, brain, spleen, pancreas, adrenals, thyroid.
Discussion:Among patients 4/7 patients were male. The mean age was 64.28 years, [51-89 years]. The mean BMI of the patients in our series was 30.1. Pre-existing hypertension was present in 5 patients, 1 patient had asthma on inhaled corticosteroids, 1 patient had B-cell leukemia, and 1 patient was being followed for rheumatoid arthritis on methotrexate. The mean time from first signs to admission to resuscitation was 6.2 days. The mean time from first sign to death was 25 days. Out of the 7 cases, 4 were due to multivisceral failure, 4 patients had a pulmonary embolism associated or not, 1 of which died from cardiogenic shock related to pulmonary embolism. 2 patients presented with septic shock on ventilator-acquired pneumonitis. There were macroscopic lesions of diffuse pneumopathy in all 7 cases, with histological lesions marked by diffuse alveolar damage characterized by abundant intra-alveolar hyaline membranes. Of the 7 patients, 4 had thromboembolic lesions either proximal (fig1) or distal, sometimes complicated by pulmonary infarction. Focal pulmonary lesions of vasculitis (fig2) were observed in 4 patients. All the patients presented lesions of acute pancreatitis sometimes visible on macroscopic examination, these lesions occurring on a pancreatic parenchyma most often abnormal, either in fat involution or at the stage of chronic pancreatitis.
According to our study, patients who died in intensive care of severe forms of Covid-19 had numerous visceral lesions impacting the major organs. There is a more pronounced tropism in the lungs with frequent thrombotic complications.
Keyword(s): SAARS-COV-2 infection, thromboembolic complications, autopsySession Type: 1-hour Oral Session
Session Title: 1-hour Oral Session
Authors(s): S. Bessis, L.M. Flora, K. Mahe, A. Djillali, G. L.d.l.g
Authors Affiliations(s): Hôpital Raymond-Poincaré, Aphp, France
Background:
Despite the emergence of SARS-Cov-2 responsible for Covid-19 since December 2019 in China, the tissue damage linked to SARS-Cov-2 is not yet well known. The aim of this work was therefore to determine the causes of death of patients infected with Covid-19 and to document anatomopathologically the lesions attributable to the SARS-Cov-2 virus on the various organs.
Case:Patients were autopsied in the Department of Pathological Anatomy and Forensic Medicine at the Raymond-Poincaré Hospital in compliance with the law on bioethics. Autopsies were performed according to Ghon's technique, and histological samples were taken from the following organs: heart, lungs, liver, kidneys, brain, spleen, pancreas, adrenals, thyroid.
Discussion:Among patients 4/7 patients were male. The mean age was 64.28 years, [51-89 years]. The mean BMI of the patients in our series was 30.1. Pre-existing hypertension was present in 5 patients, 1 patient had asthma on inhaled corticosteroids, 1 patient had B-cell leukemia, and 1 patient was being followed for rheumatoid arthritis on methotrexate. The mean time from first signs to admission to resuscitation was 6.2 days. The mean time from first sign to death was 25 days. Out of the 7 cases, 4 were due to multivisceral failure, 4 patients had a pulmonary embolism associated or not, 1 of which died from cardiogenic shock related to pulmonary embolism. 2 patients presented with septic shock on ventilator-acquired pneumonitis. There were macroscopic lesions of diffuse pneumopathy in all 7 cases, with histological lesions marked by diffuse alveolar damage characterized by abundant intra-alveolar hyaline membranes. Of the 7 patients, 4 had thromboembolic lesions either proximal (fig1) or distal, sometimes complicated by pulmonary infarction. Focal pulmonary lesions of vasculitis (fig2) were observed in 4 patients. All the patients presented lesions of acute pancreatitis sometimes visible on macroscopic examination, these lesions occurring on a pancreatic parenchyma most often abnormal, either in fat involution or at the stage of chronic pancreatitis.
According to our study, patients who died in intensive care of severe forms of Covid-19 had numerous visceral lesions impacting the major organs. There is a more pronounced tropism in the lungs with frequent thrombotic complications.
Keyword(s): SAARS-COV-2 infection, thromboembolic complications, autopsy
Session Type: 1-hour Oral Session
Session Title: 1-hour Oral Session
Authors(s): S. Bessis, L.M. Flora, K. Mahe, A. Djillali, G. L.d.l.g
Authors Affiliations(s): Hôpital Raymond-Poincaré, Aphp, France
Background:
Despite the emergence of SARS-Cov-2 responsible for Covid-19 since December 2019 in China, the tissue damage linked to SARS-Cov-2 is not yet well known. The aim of this work was therefore to determine the causes of death of patients infected with Covid-19 and to document anatomopathologically the lesions attributable to the SARS-Cov-2 virus on the various organs.
Case:Patients were autopsied in the Department of Pathological Anatomy and Forensic Medicine at the Raymond-Poincaré Hospital in compliance with the law on bioethics. Autopsies were performed according to Ghon's technique, and histological samples were taken from the following organs: heart, lungs, liver, kidneys, brain, spleen, pancreas, adrenals, thyroid.
Discussion:Among patients 4/7 patients were male. The mean age was 64.28 years, [51-89 years]. The mean BMI of the patients in our series was 30.1. Pre-existing hypertension was present in 5 patients, 1 patient had asthma on inhaled corticosteroids, 1 patient had B-cell leukemia, and 1 patient was being followed for rheumatoid arthritis on methotrexate. The mean time from first signs to admission to resuscitation was 6.2 days. The mean time from first sign to death was 25 days. Out of the 7 cases, 4 were due to multivisceral failure, 4 patients had a pulmonary embolism associated or not, 1 of which died from cardiogenic shock related to pulmonary embolism. 2 patients presented with septic shock on ventilator-acquired pneumonitis. There were macroscopic lesions of diffuse pneumopathy in all 7 cases, with histological lesions marked by diffuse alveolar damage characterized by abundant intra-alveolar hyaline membranes. Of the 7 patients, 4 had thromboembolic lesions either proximal (fig1) or distal, sometimes complicated by pulmonary infarction. Focal pulmonary lesions of vasculitis (fig2) were observed in 4 patients. All the patients presented lesions of acute pancreatitis sometimes visible on macroscopic examination, these lesions occurring on a pancreatic parenchyma most often abnormal, either in fat involution or at the stage of chronic pancreatitis.
According to our study, patients who died in intensive care of severe forms of Covid-19 had numerous visceral lesions impacting the major organs. There is a more pronounced tropism in the lungs with frequent thrombotic complications.
Keyword(s): SAARS-COV-2 infection, thromboembolic complications, autopsySession Type: 1-hour Oral Session
Session Title: 1-hour Oral Session
Authors(s): S. Bessis, L.M. Flora, K. Mahe, A. Djillali, G. L.d.l.g
Authors Affiliations(s): Hôpital Raymond-Poincaré, Aphp, France
Background:
Despite the emergence of SARS-Cov-2 responsible for Covid-19 since December 2019 in China, the tissue damage linked to SARS-Cov-2 is not yet well known. The aim of this work was therefore to determine the causes of death of patients infected with Covid-19 and to document anatomopathologically the lesions attributable to the SARS-Cov-2 virus on the various organs.
Case:Patients were autopsied in the Department of Pathological Anatomy and Forensic Medicine at the Raymond-Poincaré Hospital in compliance with the law on bioethics. Autopsies were performed according to Ghon's technique, and histological samples were taken from the following organs: heart, lungs, liver, kidneys, brain, spleen, pancreas, adrenals, thyroid.
Discussion:Among patients 4/7 patients were male. The mean age was 64.28 years, [51-89 years]. The mean BMI of the patients in our series was 30.1. Pre-existing hypertension was present in 5 patients, 1 patient had asthma on inhaled corticosteroids, 1 patient had B-cell leukemia, and 1 patient was being followed for rheumatoid arthritis on methotrexate. The mean time from first signs to admission to resuscitation was 6.2 days. The mean time from first sign to death was 25 days. Out of the 7 cases, 4 were due to multivisceral failure, 4 patients had a pulmonary embolism associated or not, 1 of which died from cardiogenic shock related to pulmonary embolism. 2 patients presented with septic shock on ventilator-acquired pneumonitis. There were macroscopic lesions of diffuse pneumopathy in all 7 cases, with histological lesions marked by diffuse alveolar damage characterized by abundant intra-alveolar hyaline membranes. Of the 7 patients, 4 had thromboembolic lesions either proximal (fig1) or distal, sometimes complicated by pulmonary infarction. Focal pulmonary lesions of vasculitis (fig2) were observed in 4 patients. All the patients presented lesions of acute pancreatitis sometimes visible on macroscopic examination, these lesions occurring on a pancreatic parenchyma most often abnormal, either in fat involution or at the stage of chronic pancreatitis.
According to our study, patients who died in intensive care of severe forms of Covid-19 had numerous visceral lesions impacting the major organs. There is a more pronounced tropism in the lungs with frequent thrombotic complications.
Keyword(s): SAARS-COV-2 infection, thromboembolic complications, autopsy