Session Type: ePosters
Session Title: ePosters
Authors(s): L. Unanue, A. Agüeros, O. Ateka, A. Camara, E. Sampedro, N. Maure, P. Arozena, A. Bayona, I. Sanz, N. Aizpitarte, M. Palou, A. Pastor, M. Fernandez
Authors Affiliations(s): Hospital Universitario Donostia, Spain
Background:
Immunological memory is the basis for protective durable immunity after vaccinations or infections. The duration of immunological memory after moderate to severe SARS-CoV-2 infection is unclear. This study aims to clarify the evolution of antibodies throughout the first 8 months after infection in patients that were admitted with pneumonia or severe infection caused by SARS-CoV-2.
Methods:We conducted a prospective study to follow up 266 patients who required hospital admission for SARS-CoV-2 infection between 1/03/2020 and 31/05/2020 at Donostia University Hospital, in San Sebastian, Spain. We measured antibodies in serum samples of all patients 4 and 8 months after hospital discharge.
Results:4 months after hospital discharge, 158 patients (59.4%) showed IgG and IgM positive antibodies, 97 patients (36.5%) showed only IgG positive antibodies, 1 patient (0.3%) showed only IgM antibodies, 2 serological tests (0.7%) were uncertain, and 8 patients (3%) showed negative serological screening. Five out of those 8 patients with negative antibodies were immunosuppressed patients, the remaining three had a mild infection and were admitted to the hospital for other reasons.
8 months after discharge, we repeated serology of 241 patients that continued in the study and had antibodies in previous blood samples. Only IgG antibodies were found in 153 patients (63.5%), IgG and IgM were found in 84 patients (34.9%), 1 serological test (0.4%) was uncertain to IgG, and 2 patients became negative (0.8%).
Conclusions:Our data suggest that a high percentage of patients with moderate and severe SARS-CoV-2 infection present persistence of antibodies up to 8 months after hospital discharge. A small percentage of patients do not keep detectable antibodies after the infection, most of whom were considered immunodeppressed patients.
Keyword(s): COVID-19, Serology, SARS-CoV-2Session Type: ePosters
Session Title: ePosters
Authors(s): L. Unanue, A. Agüeros, O. Ateka, A. Camara, E. Sampedro, N. Maure, P. Arozena, A. Bayona, I. Sanz, N. Aizpitarte, M. Palou, A. Pastor, M. Fernandez
Authors Affiliations(s): Hospital Universitario Donostia, Spain
Background:
Immunological memory is the basis for protective durable immunity after vaccinations or infections. The duration of immunological memory after moderate to severe SARS-CoV-2 infection is unclear. This study aims to clarify the evolution of antibodies throughout the first 8 months after infection in patients that were admitted with pneumonia or severe infection caused by SARS-CoV-2.
Methods:We conducted a prospective study to follow up 266 patients who required hospital admission for SARS-CoV-2 infection between 1/03/2020 and 31/05/2020 at Donostia University Hospital, in San Sebastian, Spain. We measured antibodies in serum samples of all patients 4 and 8 months after hospital discharge.
Results:4 months after hospital discharge, 158 patients (59.4%) showed IgG and IgM positive antibodies, 97 patients (36.5%) showed only IgG positive antibodies, 1 patient (0.3%) showed only IgM antibodies, 2 serological tests (0.7%) were uncertain, and 8 patients (3%) showed negative serological screening. Five out of those 8 patients with negative antibodies were immunosuppressed patients, the remaining three had a mild infection and were admitted to the hospital for other reasons.
8 months after discharge, we repeated serology of 241 patients that continued in the study and had antibodies in previous blood samples. Only IgG antibodies were found in 153 patients (63.5%), IgG and IgM were found in 84 patients (34.9%), 1 serological test (0.4%) was uncertain to IgG, and 2 patients became negative (0.8%).
Conclusions:Our data suggest that a high percentage of patients with moderate and severe SARS-CoV-2 infection present persistence of antibodies up to 8 months after hospital discharge. A small percentage of patients do not keep detectable antibodies after the infection, most of whom were considered immunodeppressed patients.
Keyword(s): COVID-19, Serology, SARS-CoV-2
Session Type: ePosters
Session Title: ePosters
Authors(s): L. Unanue, A. Agüeros, O. Ateka, A. Camara, E. Sampedro, N. Maure, P. Arozena, A. Bayona, I. Sanz, N. Aizpitarte, M. Palou, A. Pastor, M. Fernandez
Authors Affiliations(s): Hospital Universitario Donostia, Spain
Background:
Immunological memory is the basis for protective durable immunity after vaccinations or infections. The duration of immunological memory after moderate to severe SARS-CoV-2 infection is unclear. This study aims to clarify the evolution of antibodies throughout the first 8 months after infection in patients that were admitted with pneumonia or severe infection caused by SARS-CoV-2.
Methods:We conducted a prospective study to follow up 266 patients who required hospital admission for SARS-CoV-2 infection between 1/03/2020 and 31/05/2020 at Donostia University Hospital, in San Sebastian, Spain. We measured antibodies in serum samples of all patients 4 and 8 months after hospital discharge.
Results:4 months after hospital discharge, 158 patients (59.4%) showed IgG and IgM positive antibodies, 97 patients (36.5%) showed only IgG positive antibodies, 1 patient (0.3%) showed only IgM antibodies, 2 serological tests (0.7%) were uncertain, and 8 patients (3%) showed negative serological screening. Five out of those 8 patients with negative antibodies were immunosuppressed patients, the remaining three had a mild infection and were admitted to the hospital for other reasons.
8 months after discharge, we repeated serology of 241 patients that continued in the study and had antibodies in previous blood samples. Only IgG antibodies were found in 153 patients (63.5%), IgG and IgM were found in 84 patients (34.9%), 1 serological test (0.4%) was uncertain to IgG, and 2 patients became negative (0.8%).
Conclusions:Our data suggest that a high percentage of patients with moderate and severe SARS-CoV-2 infection present persistence of antibodies up to 8 months after hospital discharge. A small percentage of patients do not keep detectable antibodies after the infection, most of whom were considered immunodeppressed patients.
Keyword(s): COVID-19, Serology, SARS-CoV-2Session Type: ePosters
Session Title: ePosters
Authors(s): L. Unanue, A. Agüeros, O. Ateka, A. Camara, E. Sampedro, N. Maure, P. Arozena, A. Bayona, I. Sanz, N. Aizpitarte, M. Palou, A. Pastor, M. Fernandez
Authors Affiliations(s): Hospital Universitario Donostia, Spain
Background:
Immunological memory is the basis for protective durable immunity after vaccinations or infections. The duration of immunological memory after moderate to severe SARS-CoV-2 infection is unclear. This study aims to clarify the evolution of antibodies throughout the first 8 months after infection in patients that were admitted with pneumonia or severe infection caused by SARS-CoV-2.
Methods:We conducted a prospective study to follow up 266 patients who required hospital admission for SARS-CoV-2 infection between 1/03/2020 and 31/05/2020 at Donostia University Hospital, in San Sebastian, Spain. We measured antibodies in serum samples of all patients 4 and 8 months after hospital discharge.
Results:4 months after hospital discharge, 158 patients (59.4%) showed IgG and IgM positive antibodies, 97 patients (36.5%) showed only IgG positive antibodies, 1 patient (0.3%) showed only IgM antibodies, 2 serological tests (0.7%) were uncertain, and 8 patients (3%) showed negative serological screening. Five out of those 8 patients with negative antibodies were immunosuppressed patients, the remaining three had a mild infection and were admitted to the hospital for other reasons.
8 months after discharge, we repeated serology of 241 patients that continued in the study and had antibodies in previous blood samples. Only IgG antibodies were found in 153 patients (63.5%), IgG and IgM were found in 84 patients (34.9%), 1 serological test (0.4%) was uncertain to IgG, and 2 patients became negative (0.8%).
Conclusions:Our data suggest that a high percentage of patients with moderate and severe SARS-CoV-2 infection present persistence of antibodies up to 8 months after hospital discharge. A small percentage of patients do not keep detectable antibodies after the infection, most of whom were considered immunodeppressed patients.
Keyword(s): COVID-19, Serology, SARS-CoV-2