Session Type: ePosters
Session Title: ePosters
Authors(s): E. Lagarejos Gonzalez (1), L. Urquia (2), J. Poch (3), M. Hernandez (4), A. Ribary (5), M. Andjuar (6), I. Campos-Herrero (1)
Authors Affiliations(s): (1) Microbiology Service, Hospital Universitario de Gran Canaria Dr. Negrín, Spain, (2) Neonatology Service, Hospital Universitario Materno Infantil, Spain, (3) Pediatric Infectious disseases Unit, Hospital Universitario Materno Infantil, Spain, (4) Infectious disseases Unit, Hospital Universitario Materno Infantil, Spain, (5) Ginecology Service, Hospital Universitario Materno Infantil, Spain, (6) Pathology Service, Hospital Universitario Materno Infantil, Spain
Background:
Genital tuberculosis (GTB) is a cause of infertility. Since the introduction of in- vitro fertilisation (IVF) as treatment for infertility, congenital tuberculosis (CTB) cases after IVF have been reported. We aime to describe two cases of babies born with CTB after IVFin Spain and review reported cases.
Methods: a literature review of Medline was conducted using as key words “congenital tuberculosis” and “in vitro fertilisation”.
Case:A 30-year-old spanish woman, with no significant medical history, succesfully underwent IVF. Previous month to delivery she had cough, fever and night sweats and subsequently, intermittent fever empirically treated with antibiotics without improvement. At 28 weeks gestation, chorioamnionitis was diagnosed, a caesarean section performed and twins were born. Both neonates were admitted to the neonatal Intensive Care Unit due to respiratory distress requiring non-invasive mechanical ventilation.
Regarding the mother, because of the persistent fever, an endometrial biopsy was made that showed granulomas and AFB. A positive Mycobacterium tuberculosis complex (MTC) polymerase chain reaction (PCR) was obtained and subsequently grew drug susceptible MTC. Once GTB diagnosis was achieved, newborns were evaluated for CTB on day of life 18. Both babies had AFB and positive MTC PCR and culture in gastric aspirates. An abdominal ultrasound revealed liver lesions highly suggestive of granulomas in twin 2.
Antituberculous therapy was started in mother and children.
As for the outcome of the babies, respiratory support was stopped on day of life 53 (twin1) and 48 (twin 2). Twin 1, at 2 months of age, still in hospital, developed an inflamed, enlarged left submandibular lymph node and further cervical adenopathies were noted after 4 months of antituberculous therapy. All lymphadenopathies were surgically removed. They were discharged from hospital when they were 2 and 3- months old respectively.
All three patients completed 12 months of treatment with isoniazid and rifampicin (plus pirazinamyde the first two months) and they totally recovered.
Reported cases in the literature and ours are summarized in table 1 and 2.
Discussion:We found 19 reported cases of babies born with CTB after IVF in the literature and we described two more cases, the first ones diagnosed in Spain.
Keyword(s): Congenital tuberculosis, In vitro fertilisationSession Type: ePosters
Session Title: ePosters
Authors(s): E. Lagarejos Gonzalez (1), L. Urquia (2), J. Poch (3), M. Hernandez (4), A. Ribary (5), M. Andjuar (6), I. Campos-Herrero (1)
Authors Affiliations(s): (1) Microbiology Service, Hospital Universitario de Gran Canaria Dr. Negrín, Spain, (2) Neonatology Service, Hospital Universitario Materno Infantil, Spain, (3) Pediatric Infectious disseases Unit, Hospital Universitario Materno Infantil, Spain, (4) Infectious disseases Unit, Hospital Universitario Materno Infantil, Spain, (5) Ginecology Service, Hospital Universitario Materno Infantil, Spain, (6) Pathology Service, Hospital Universitario Materno Infantil, Spain
Background:
Genital tuberculosis (GTB) is a cause of infertility. Since the introduction of in- vitro fertilisation (IVF) as treatment for infertility, congenital tuberculosis (CTB) cases after IVF have been reported. We aime to describe two cases of babies born with CTB after IVFin Spain and review reported cases.
Methods: a literature review of Medline was conducted using as key words “congenital tuberculosis” and “in vitro fertilisation”.
Case:A 30-year-old spanish woman, with no significant medical history, succesfully underwent IVF. Previous month to delivery she had cough, fever and night sweats and subsequently, intermittent fever empirically treated with antibiotics without improvement. At 28 weeks gestation, chorioamnionitis was diagnosed, a caesarean section performed and twins were born. Both neonates were admitted to the neonatal Intensive Care Unit due to respiratory distress requiring non-invasive mechanical ventilation.
Regarding the mother, because of the persistent fever, an endometrial biopsy was made that showed granulomas and AFB. A positive Mycobacterium tuberculosis complex (MTC) polymerase chain reaction (PCR) was obtained and subsequently grew drug susceptible MTC. Once GTB diagnosis was achieved, newborns were evaluated for CTB on day of life 18. Both babies had AFB and positive MTC PCR and culture in gastric aspirates. An abdominal ultrasound revealed liver lesions highly suggestive of granulomas in twin 2.
Antituberculous therapy was started in mother and children.
As for the outcome of the babies, respiratory support was stopped on day of life 53 (twin1) and 48 (twin 2). Twin 1, at 2 months of age, still in hospital, developed an inflamed, enlarged left submandibular lymph node and further cervical adenopathies were noted after 4 months of antituberculous therapy. All lymphadenopathies were surgically removed. They were discharged from hospital when they were 2 and 3- months old respectively.
All three patients completed 12 months of treatment with isoniazid and rifampicin (plus pirazinamyde the first two months) and they totally recovered.
Reported cases in the literature and ours are summarized in table 1 and 2.
Discussion:We found 19 reported cases of babies born with CTB after IVF in the literature and we described two more cases, the first ones diagnosed in Spain.
Keyword(s): Congenital tuberculosis, In vitro fertilisation
Session Type: ePosters
Session Title: ePosters
Authors(s): E. Lagarejos Gonzalez (1), L. Urquia (2), J. Poch (3), M. Hernandez (4), A. Ribary (5), M. Andjuar (6), I. Campos-Herrero (1)
Authors Affiliations(s): (1) Microbiology Service, Hospital Universitario de Gran Canaria Dr. Negrín, Spain, (2) Neonatology Service, Hospital Universitario Materno Infantil, Spain, (3) Pediatric Infectious disseases Unit, Hospital Universitario Materno Infantil, Spain, (4) Infectious disseases Unit, Hospital Universitario Materno Infantil, Spain, (5) Ginecology Service, Hospital Universitario Materno Infantil, Spain, (6) Pathology Service, Hospital Universitario Materno Infantil, Spain
Background:
Genital tuberculosis (GTB) is a cause of infertility. Since the introduction of in- vitro fertilisation (IVF) as treatment for infertility, congenital tuberculosis (CTB) cases after IVF have been reported. We aime to describe two cases of babies born with CTB after IVFin Spain and review reported cases.
Methods: a literature review of Medline was conducted using as key words “congenital tuberculosis” and “in vitro fertilisation”.
Case:A 30-year-old spanish woman, with no significant medical history, succesfully underwent IVF. Previous month to delivery she had cough, fever and night sweats and subsequently, intermittent fever empirically treated with antibiotics without improvement. At 28 weeks gestation, chorioamnionitis was diagnosed, a caesarean section performed and twins were born. Both neonates were admitted to the neonatal Intensive Care Unit due to respiratory distress requiring non-invasive mechanical ventilation.
Regarding the mother, because of the persistent fever, an endometrial biopsy was made that showed granulomas and AFB. A positive Mycobacterium tuberculosis complex (MTC) polymerase chain reaction (PCR) was obtained and subsequently grew drug susceptible MTC. Once GTB diagnosis was achieved, newborns were evaluated for CTB on day of life 18. Both babies had AFB and positive MTC PCR and culture in gastric aspirates. An abdominal ultrasound revealed liver lesions highly suggestive of granulomas in twin 2.
Antituberculous therapy was started in mother and children.
As for the outcome of the babies, respiratory support was stopped on day of life 53 (twin1) and 48 (twin 2). Twin 1, at 2 months of age, still in hospital, developed an inflamed, enlarged left submandibular lymph node and further cervical adenopathies were noted after 4 months of antituberculous therapy. All lymphadenopathies were surgically removed. They were discharged from hospital when they were 2 and 3- months old respectively.
All three patients completed 12 months of treatment with isoniazid and rifampicin (plus pirazinamyde the first two months) and they totally recovered.
Reported cases in the literature and ours are summarized in table 1 and 2.
Discussion:We found 19 reported cases of babies born with CTB after IVF in the literature and we described two more cases, the first ones diagnosed in Spain.
Keyword(s): Congenital tuberculosis, In vitro fertilisationSession Type: ePosters
Session Title: ePosters
Authors(s): E. Lagarejos Gonzalez (1), L. Urquia (2), J. Poch (3), M. Hernandez (4), A. Ribary (5), M. Andjuar (6), I. Campos-Herrero (1)
Authors Affiliations(s): (1) Microbiology Service, Hospital Universitario de Gran Canaria Dr. Negrín, Spain, (2) Neonatology Service, Hospital Universitario Materno Infantil, Spain, (3) Pediatric Infectious disseases Unit, Hospital Universitario Materno Infantil, Spain, (4) Infectious disseases Unit, Hospital Universitario Materno Infantil, Spain, (5) Ginecology Service, Hospital Universitario Materno Infantil, Spain, (6) Pathology Service, Hospital Universitario Materno Infantil, Spain
Background:
Genital tuberculosis (GTB) is a cause of infertility. Since the introduction of in- vitro fertilisation (IVF) as treatment for infertility, congenital tuberculosis (CTB) cases after IVF have been reported. We aime to describe two cases of babies born with CTB after IVFin Spain and review reported cases.
Methods: a literature review of Medline was conducted using as key words “congenital tuberculosis” and “in vitro fertilisation”.
Case:A 30-year-old spanish woman, with no significant medical history, succesfully underwent IVF. Previous month to delivery she had cough, fever and night sweats and subsequently, intermittent fever empirically treated with antibiotics without improvement. At 28 weeks gestation, chorioamnionitis was diagnosed, a caesarean section performed and twins were born. Both neonates were admitted to the neonatal Intensive Care Unit due to respiratory distress requiring non-invasive mechanical ventilation.
Regarding the mother, because of the persistent fever, an endometrial biopsy was made that showed granulomas and AFB. A positive Mycobacterium tuberculosis complex (MTC) polymerase chain reaction (PCR) was obtained and subsequently grew drug susceptible MTC. Once GTB diagnosis was achieved, newborns were evaluated for CTB on day of life 18. Both babies had AFB and positive MTC PCR and culture in gastric aspirates. An abdominal ultrasound revealed liver lesions highly suggestive of granulomas in twin 2.
Antituberculous therapy was started in mother and children.
As for the outcome of the babies, respiratory support was stopped on day of life 53 (twin1) and 48 (twin 2). Twin 1, at 2 months of age, still in hospital, developed an inflamed, enlarged left submandibular lymph node and further cervical adenopathies were noted after 4 months of antituberculous therapy. All lymphadenopathies were surgically removed. They were discharged from hospital when they were 2 and 3- months old respectively.
All three patients completed 12 months of treatment with isoniazid and rifampicin (plus pirazinamyde the first two months) and they totally recovered.
Reported cases in the literature and ours are summarized in table 1 and 2.
Discussion:We found 19 reported cases of babies born with CTB after IVF in the literature and we described two more cases, the first ones diagnosed in Spain.
Keyword(s): Congenital tuberculosis, In vitro fertilisation