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Abstract
Discussion Forum (0)
Abstract number: 3580

Session Type: ePosters

Session Title: ePosters

Authors(s): R. Martinez Pérez, G. Santillana Cernuda, Y. García Collado, E. Clavijo Frutos, M.V. García López

Authors Affiliations(s): Servicio de Microbiología Clínica y Parasitología Hospital Universitario Virgen de la Victoria, Spain

Background:

Pseudomonas aeruginosa (PA) is characterized by the intrinsic resistance to antibiotics with β-lactamase expression and the production of efflux pumps.

It has a high capacity to develop resistance to practically all available antibiotics being one of the main causes of nosocomial infection.

The aim of this study is to determine the antibiotic sensitivity profile of PA bacteremia at the Hospital Universitario Virgen de la Victoria (HUVV), to evaluate the epidemiological factors and their fatality rate.

Methods:

Retrospective analysis of clinical and microbiological aspects of PA bacteremia over a 9-year period in the HUVV.

For identification and sensitivity study MicroScan WalkAway system (Beckman Coulter) was used for the first 6 years and Vitek®2 system (Biomérieux) from 2017.

The sensitivity interpretation was carried out in the first period with CLSI, and in the second with EUCAST. The categorization of PA into multidrug-resistant (MDR), extensively drug-resistant (XDR) and pandrug-resistant (PDR) was carried out using EUCAST criteria.

Results:

59% of the patients were men, with an average age of 65 years. The acquisition of bacteremia was mainly nosocomial or health-care associated infections (35% and 30%, respectively). The most frequent comorbidities were neoplasia (31%), renal failure (30%), diabetes mellitus (22%), and heart disease (17%). 42% of the patients presented immunodeficiency, the most frequent cause was solid organ neoplasms (71%). The origin of the bacteremia was urinary (21%), followed by respiratory (15%) and gastrointestinal (9%). The crude death rate was 42% overall, 22% for PA bacteremia.

Table 1. Susceptibility of PA bacteremia in HUVV (2011-2020)
Antibiotics

Global sensitivity

(n=223)

Piperacilin/tazobactam 90%
Ceftazidime 87%
Cefepime 89%
Imipinem 84%
Meropenem 87%
Ciprofloxacin 84%
Amikacin 98%
Gentamicin 96%
Tobramycin 98%
Colistin 97%
Fosfomycin 44%

Only 13 (5.8%) MDR strains and 2 (0.9%) XDR strains were detected during the entire study period.

Conclusions:

The percentages of antibiotic sensitivity of PA in our environment continue to be high. The multi-resistance frequency is unusual. The crude death rate was 42% overall, 22% for infectious process.

Therefore, the sensitivity study is essential to detect possible high-risk clones (HRCs).

Keyword(s): Pseudomonas aeruginosa, Bacteremia, Antimicrobial susceptibility

Abstract number: 3580

Session Type: ePosters

Session Title: ePosters

Authors(s): R. Martinez Pérez, G. Santillana Cernuda, Y. García Collado, E. Clavijo Frutos, M.V. García López

Authors Affiliations(s): Servicio de Microbiología Clínica y Parasitología Hospital Universitario Virgen de la Victoria, Spain

Background:

Pseudomonas aeruginosa (PA) is characterized by the intrinsic resistance to antibiotics with β-lactamase expression and the production of efflux pumps.

It has a high capacity to develop resistance to practically all available antibiotics being one of the main causes of nosocomial infection.

The aim of this study is to determine the antibiotic sensitivity profile of PA bacteremia at the Hospital Universitario Virgen de la Victoria (HUVV), to evaluate the epidemiological factors and their fatality rate.

Methods:

Retrospective analysis of clinical and microbiological aspects of PA bacteremia over a 9-year period in the HUVV.

For identification and sensitivity study MicroScan WalkAway system (Beckman Coulter) was used for the first 6 years and Vitek®2 system (Biomérieux) from 2017.

The sensitivity interpretation was carried out in the first period with CLSI, and in the second with EUCAST. The categorization of PA into multidrug-resistant (MDR), extensively drug-resistant (XDR) and pandrug-resistant (PDR) was carried out using EUCAST criteria.

Results:

59% of the patients were men, with an average age of 65 years. The acquisition of bacteremia was mainly nosocomial or health-care associated infections (35% and 30%, respectively). The most frequent comorbidities were neoplasia (31%), renal failure (30%), diabetes mellitus (22%), and heart disease (17%). 42% of the patients presented immunodeficiency, the most frequent cause was solid organ neoplasms (71%). The origin of the bacteremia was urinary (21%), followed by respiratory (15%) and gastrointestinal (9%). The crude death rate was 42% overall, 22% for PA bacteremia.

Table 1. Susceptibility of PA bacteremia in HUVV (2011-2020)
Antibiotics

Global sensitivity

(n=223)

Piperacilin/tazobactam 90%
Ceftazidime 87%
Cefepime 89%
Imipinem 84%
Meropenem 87%
Ciprofloxacin 84%
Amikacin 98%
Gentamicin 96%
Tobramycin 98%
Colistin 97%
Fosfomycin 44%

Only 13 (5.8%) MDR strains and 2 (0.9%) XDR strains were detected during the entire study period.

Conclusions:

The percentages of antibiotic sensitivity of PA in our environment continue to be high. The multi-resistance frequency is unusual. The crude death rate was 42% overall, 22% for infectious process.

Therefore, the sensitivity study is essential to detect possible high-risk clones (HRCs).

Keyword(s): Pseudomonas aeruginosa, Bacteremia, Antimicrobial susceptibility

Antimicrobial susceptibility of Pseudomonas aeruginosa bacteremia in Málaga, Spain: a nine-year study
Rocío Martinez Pérez
Rocío Martinez Pérez
ESCMID eAcademy. Martinez Pérez R. 07/09/2021; 329427; 3580;
user
Rocío Martinez Pérez
Abstract
Discussion Forum (0)
Abstract number: 3580

Session Type: ePosters

Session Title: ePosters

Authors(s): R. Martinez Pérez, G. Santillana Cernuda, Y. García Collado, E. Clavijo Frutos, M.V. García López

Authors Affiliations(s): Servicio de Microbiología Clínica y Parasitología Hospital Universitario Virgen de la Victoria, Spain

Background:

Pseudomonas aeruginosa (PA) is characterized by the intrinsic resistance to antibiotics with β-lactamase expression and the production of efflux pumps.

It has a high capacity to develop resistance to practically all available antibiotics being one of the main causes of nosocomial infection.

The aim of this study is to determine the antibiotic sensitivity profile of PA bacteremia at the Hospital Universitario Virgen de la Victoria (HUVV), to evaluate the epidemiological factors and their fatality rate.

Methods:

Retrospective analysis of clinical and microbiological aspects of PA bacteremia over a 9-year period in the HUVV.

For identification and sensitivity study MicroScan WalkAway system (Beckman Coulter) was used for the first 6 years and Vitek®2 system (Biomérieux) from 2017.

The sensitivity interpretation was carried out in the first period with CLSI, and in the second with EUCAST. The categorization of PA into multidrug-resistant (MDR), extensively drug-resistant (XDR) and pandrug-resistant (PDR) was carried out using EUCAST criteria.

Results:

59% of the patients were men, with an average age of 65 years. The acquisition of bacteremia was mainly nosocomial or health-care associated infections (35% and 30%, respectively). The most frequent comorbidities were neoplasia (31%), renal failure (30%), diabetes mellitus (22%), and heart disease (17%). 42% of the patients presented immunodeficiency, the most frequent cause was solid organ neoplasms (71%). The origin of the bacteremia was urinary (21%), followed by respiratory (15%) and gastrointestinal (9%). The crude death rate was 42% overall, 22% for PA bacteremia.

Table 1. Susceptibility of PA bacteremia in HUVV (2011-2020)
Antibiotics

Global sensitivity

(n=223)

Piperacilin/tazobactam 90%
Ceftazidime 87%
Cefepime 89%
Imipinem 84%
Meropenem 87%
Ciprofloxacin 84%
Amikacin 98%
Gentamicin 96%
Tobramycin 98%
Colistin 97%
Fosfomycin 44%

Only 13 (5.8%) MDR strains and 2 (0.9%) XDR strains were detected during the entire study period.

Conclusions:

The percentages of antibiotic sensitivity of PA in our environment continue to be high. The multi-resistance frequency is unusual. The crude death rate was 42% overall, 22% for infectious process.

Therefore, the sensitivity study is essential to detect possible high-risk clones (HRCs).

Keyword(s): Pseudomonas aeruginosa, Bacteremia, Antimicrobial susceptibility

Abstract number: 3580

Session Type: ePosters

Session Title: ePosters

Authors(s): R. Martinez Pérez, G. Santillana Cernuda, Y. García Collado, E. Clavijo Frutos, M.V. García López

Authors Affiliations(s): Servicio de Microbiología Clínica y Parasitología Hospital Universitario Virgen de la Victoria, Spain

Background:

Pseudomonas aeruginosa (PA) is characterized by the intrinsic resistance to antibiotics with β-lactamase expression and the production of efflux pumps.

It has a high capacity to develop resistance to practically all available antibiotics being one of the main causes of nosocomial infection.

The aim of this study is to determine the antibiotic sensitivity profile of PA bacteremia at the Hospital Universitario Virgen de la Victoria (HUVV), to evaluate the epidemiological factors and their fatality rate.

Methods:

Retrospective analysis of clinical and microbiological aspects of PA bacteremia over a 9-year period in the HUVV.

For identification and sensitivity study MicroScan WalkAway system (Beckman Coulter) was used for the first 6 years and Vitek®2 system (Biomérieux) from 2017.

The sensitivity interpretation was carried out in the first period with CLSI, and in the second with EUCAST. The categorization of PA into multidrug-resistant (MDR), extensively drug-resistant (XDR) and pandrug-resistant (PDR) was carried out using EUCAST criteria.

Results:

59% of the patients were men, with an average age of 65 years. The acquisition of bacteremia was mainly nosocomial or health-care associated infections (35% and 30%, respectively). The most frequent comorbidities were neoplasia (31%), renal failure (30%), diabetes mellitus (22%), and heart disease (17%). 42% of the patients presented immunodeficiency, the most frequent cause was solid organ neoplasms (71%). The origin of the bacteremia was urinary (21%), followed by respiratory (15%) and gastrointestinal (9%). The crude death rate was 42% overall, 22% for PA bacteremia.

Table 1. Susceptibility of PA bacteremia in HUVV (2011-2020)
Antibiotics

Global sensitivity

(n=223)

Piperacilin/tazobactam 90%
Ceftazidime 87%
Cefepime 89%
Imipinem 84%
Meropenem 87%
Ciprofloxacin 84%
Amikacin 98%
Gentamicin 96%
Tobramycin 98%
Colistin 97%
Fosfomycin 44%

Only 13 (5.8%) MDR strains and 2 (0.9%) XDR strains were detected during the entire study period.

Conclusions:

The percentages of antibiotic sensitivity of PA in our environment continue to be high. The multi-resistance frequency is unusual. The crude death rate was 42% overall, 22% for infectious process.

Therefore, the sensitivity study is essential to detect possible high-risk clones (HRCs).

Keyword(s): Pseudomonas aeruginosa, Bacteremia, Antimicrobial susceptibility

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