Session Type: ePosters
Session Title: ePosters
Authors(s): R. Martinez Pérez, G. Santillana Cernuda, Y. García Collado, E. Clavijo Frutos, M.V. García López
Authors Affiliations(s): Servicio de Microbiología Clínica y Parasitología Hospital Universitario Virgen de la Victoria, Spain
Background:
Pseudomonas aeruginosa (PA) is characterized by the intrinsic resistance to antibiotics with β-lactamase expression and the production of efflux pumps.
It has a high capacity to develop resistance to practically all available antibiotics being one of the main causes of nosocomial infection.
The aim of this study is to determine the antibiotic sensitivity profile of PA bacteremia at the Hospital Universitario Virgen de la Victoria (HUVV), to evaluate the epidemiological factors and their fatality rate.
Methods:Retrospective analysis of clinical and microbiological aspects of PA bacteremia over a 9-year period in the HUVV.
For identification and sensitivity study MicroScan WalkAway system (Beckman Coulter) was used for the first 6 years and Vitek®2 system (Biomérieux) from 2017.
The sensitivity interpretation was carried out in the first period with CLSI, and in the second with EUCAST. The categorization of PA into multidrug-resistant (MDR), extensively drug-resistant (XDR) and pandrug-resistant (PDR) was carried out using EUCAST criteria.
Results:59% of the patients were men, with an average age of 65 years. The acquisition of bacteremia was mainly nosocomial or health-care associated infections (35% and 30%, respectively). The most frequent comorbidities were neoplasia (31%), renal failure (30%), diabetes mellitus (22%), and heart disease (17%). 42% of the patients presented immunodeficiency, the most frequent cause was solid organ neoplasms (71%). The origin of the bacteremia was urinary (21%), followed by respiratory (15%) and gastrointestinal (9%). The crude death rate was 42% overall, 22% for PA bacteremia.
Antibiotics | Global sensitivity (n=223) |
---|---|
Piperacilin/tazobactam | 90% |
Ceftazidime | 87% |
Cefepime | 89% |
Imipinem | 84% |
Meropenem | 87% |
Ciprofloxacin | 84% |
Amikacin | 98% |
Gentamicin | 96% |
Tobramycin | 98% |
Colistin | 97% |
Fosfomycin | 44% |
Only 13 (5.8%) MDR strains and 2 (0.9%) XDR strains were detected during the entire study period.
Conclusions:The percentages of antibiotic sensitivity of PA in our environment continue to be high. The multi-resistance frequency is unusual. The crude death rate was 42% overall, 22% for infectious process.
Therefore, the sensitivity study is essential to detect possible high-risk clones (HRCs).
Keyword(s): Pseudomonas aeruginosa, Bacteremia, Antimicrobial susceptibilitySession Type: ePosters
Session Title: ePosters
Authors(s): R. Martinez Pérez, G. Santillana Cernuda, Y. García Collado, E. Clavijo Frutos, M.V. García López
Authors Affiliations(s): Servicio de Microbiología Clínica y Parasitología Hospital Universitario Virgen de la Victoria, Spain
Background:
Pseudomonas aeruginosa (PA) is characterized by the intrinsic resistance to antibiotics with β-lactamase expression and the production of efflux pumps.
It has a high capacity to develop resistance to practically all available antibiotics being one of the main causes of nosocomial infection.
The aim of this study is to determine the antibiotic sensitivity profile of PA bacteremia at the Hospital Universitario Virgen de la Victoria (HUVV), to evaluate the epidemiological factors and their fatality rate.
Methods:Retrospective analysis of clinical and microbiological aspects of PA bacteremia over a 9-year period in the HUVV.
For identification and sensitivity study MicroScan WalkAway system (Beckman Coulter) was used for the first 6 years and Vitek®2 system (Biomérieux) from 2017.
The sensitivity interpretation was carried out in the first period with CLSI, and in the second with EUCAST. The categorization of PA into multidrug-resistant (MDR), extensively drug-resistant (XDR) and pandrug-resistant (PDR) was carried out using EUCAST criteria.
Results:59% of the patients were men, with an average age of 65 years. The acquisition of bacteremia was mainly nosocomial or health-care associated infections (35% and 30%, respectively). The most frequent comorbidities were neoplasia (31%), renal failure (30%), diabetes mellitus (22%), and heart disease (17%). 42% of the patients presented immunodeficiency, the most frequent cause was solid organ neoplasms (71%). The origin of the bacteremia was urinary (21%), followed by respiratory (15%) and gastrointestinal (9%). The crude death rate was 42% overall, 22% for PA bacteremia.
Antibiotics | Global sensitivity (n=223) |
---|---|
Piperacilin/tazobactam | 90% |
Ceftazidime | 87% |
Cefepime | 89% |
Imipinem | 84% |
Meropenem | 87% |
Ciprofloxacin | 84% |
Amikacin | 98% |
Gentamicin | 96% |
Tobramycin | 98% |
Colistin | 97% |
Fosfomycin | 44% |
Only 13 (5.8%) MDR strains and 2 (0.9%) XDR strains were detected during the entire study period.
Conclusions:The percentages of antibiotic sensitivity of PA in our environment continue to be high. The multi-resistance frequency is unusual. The crude death rate was 42% overall, 22% for infectious process.
Therefore, the sensitivity study is essential to detect possible high-risk clones (HRCs).
Keyword(s): Pseudomonas aeruginosa, Bacteremia, Antimicrobial susceptibility