Session Type: ePosters
Session Title: ePosters
Authors(s): N. Kalchanava (1), B. Ferchichi (2)
Authors Affiliations(s): (1) Vitebsk State Order of Peoples’ Friendship Medical University, Belarus, (2) Minsk Research and Practice Center of surgery, transplantology and hematology, Belarus
Background:
COVID-19 primarily causes respiratory tract lesion. According to recent studies, patients may have ulcers, dry mouth, cracked lips or tongue, pinpoint hemorrhages, fungal infections of the oral cavity.
Purpose. To assess the state of local immunity of the oral cavity in patients after COVID-19.
Methods:The study involved 48 post-COVID-19 patients and on 28 healthy people. Saliva was used as a biological material, in which the level of sIgA (Saliva ELISA kit, Euroimmun, Germany), elastase, and BAPNA-amidase activity (Sigma-Aldrich, USA) was determined.
Results:The amount of sIgA in saliva in patients during the rehabilitation period after COVID-19 was 592.67; 254.23-944.39 μg/ml, which is higher than in the control group (p<0.05).
Depending on the timing of the disease, patients with COVID-19 showed a statistically significant increase in sIgA values after 7 days and increased up to 30 days from the start of treatment (Table 1).
The level of neutrophil elastase activity in saliva was lower in patients after COVID-19 (9.1×10-5; 0.7×10-5-42.3×10-5 pkat) than that in the control group 90×10-5; 20×10-5-13×10-5 pkat (p<0.001).
The level of BAPNA-amidase activity did not differ from the control group (p>0.05). In the control group, this indicator was 2.6; 1.59-3.79 pkat, whereas in patients with COVID-19 the values were 2.9; 1.46-3.99 pkat. When analyzing this data over time, it was found that BAPNA-amidase activity increases in patients whose disease duration was 30 days or more (Table 2).
Manifestations on oral mucosa were found in 26 people, 54.2%. The frequency of oral mucosa lesions was higher in patients in the early stages of rehabilitation and whose disease duration exceeded 30 days (Table 3).
Conclusions:Post-COVID-19 patients had a high level of sIgA and BAPNA-amidase activity in saliva, while the level of neutrophil elastase activity is 10 times lower (p<0.001). A statistically significant decrease in sIgA level occurs during the rehabilitation period 3-6 months (p=0.006).
Lesions of the oral mucosa were more common in patients in the early stages of rehabilitation (1 month after COVID-19), as well as in patients whose disease duration exceeded 30 days, while in both cases there was a high level of sIgA in saliva.
Keyword(s): COVID-19, sIgA, salivaSession Type: ePosters
Session Title: ePosters
Authors(s): N. Kalchanava (1), B. Ferchichi (2)
Authors Affiliations(s): (1) Vitebsk State Order of Peoples’ Friendship Medical University, Belarus, (2) Minsk Research and Practice Center of surgery, transplantology and hematology, Belarus
Background:
COVID-19 primarily causes respiratory tract lesion. According to recent studies, patients may have ulcers, dry mouth, cracked lips or tongue, pinpoint hemorrhages, fungal infections of the oral cavity.
Purpose. To assess the state of local immunity of the oral cavity in patients after COVID-19.
Methods:The study involved 48 post-COVID-19 patients and on 28 healthy people. Saliva was used as a biological material, in which the level of sIgA (Saliva ELISA kit, Euroimmun, Germany), elastase, and BAPNA-amidase activity (Sigma-Aldrich, USA) was determined.
Results:The amount of sIgA in saliva in patients during the rehabilitation period after COVID-19 was 592.67; 254.23-944.39 μg/ml, which is higher than in the control group (p<0.05).
Depending on the timing of the disease, patients with COVID-19 showed a statistically significant increase in sIgA values after 7 days and increased up to 30 days from the start of treatment (Table 1).
The level of neutrophil elastase activity in saliva was lower in patients after COVID-19 (9.1×10-5; 0.7×10-5-42.3×10-5 pkat) than that in the control group 90×10-5; 20×10-5-13×10-5 pkat (p<0.001).
The level of BAPNA-amidase activity did not differ from the control group (p>0.05). In the control group, this indicator was 2.6; 1.59-3.79 pkat, whereas in patients with COVID-19 the values were 2.9; 1.46-3.99 pkat. When analyzing this data over time, it was found that BAPNA-amidase activity increases in patients whose disease duration was 30 days or more (Table 2).
Manifestations on oral mucosa were found in 26 people, 54.2%. The frequency of oral mucosa lesions was higher in patients in the early stages of rehabilitation and whose disease duration exceeded 30 days (Table 3).
Conclusions:Post-COVID-19 patients had a high level of sIgA and BAPNA-amidase activity in saliva, while the level of neutrophil elastase activity is 10 times lower (p<0.001). A statistically significant decrease in sIgA level occurs during the rehabilitation period 3-6 months (p=0.006).
Lesions of the oral mucosa were more common in patients in the early stages of rehabilitation (1 month after COVID-19), as well as in patients whose disease duration exceeded 30 days, while in both cases there was a high level of sIgA in saliva.
Keyword(s): COVID-19, sIgA, saliva
Session Type: ePosters
Session Title: ePosters
Authors(s): N. Kalchanava (1), B. Ferchichi (2)
Authors Affiliations(s): (1) Vitebsk State Order of Peoples’ Friendship Medical University, Belarus, (2) Minsk Research and Practice Center of surgery, transplantology and hematology, Belarus
Background:
COVID-19 primarily causes respiratory tract lesion. According to recent studies, patients may have ulcers, dry mouth, cracked lips or tongue, pinpoint hemorrhages, fungal infections of the oral cavity.
Purpose. To assess the state of local immunity of the oral cavity in patients after COVID-19.
Methods:The study involved 48 post-COVID-19 patients and on 28 healthy people. Saliva was used as a biological material, in which the level of sIgA (Saliva ELISA kit, Euroimmun, Germany), elastase, and BAPNA-amidase activity (Sigma-Aldrich, USA) was determined.
Results:The amount of sIgA in saliva in patients during the rehabilitation period after COVID-19 was 592.67; 254.23-944.39 μg/ml, which is higher than in the control group (p<0.05).
Depending on the timing of the disease, patients with COVID-19 showed a statistically significant increase in sIgA values after 7 days and increased up to 30 days from the start of treatment (Table 1).
The level of neutrophil elastase activity in saliva was lower in patients after COVID-19 (9.1×10-5; 0.7×10-5-42.3×10-5 pkat) than that in the control group 90×10-5; 20×10-5-13×10-5 pkat (p<0.001).
The level of BAPNA-amidase activity did not differ from the control group (p>0.05). In the control group, this indicator was 2.6; 1.59-3.79 pkat, whereas in patients with COVID-19 the values were 2.9; 1.46-3.99 pkat. When analyzing this data over time, it was found that BAPNA-amidase activity increases in patients whose disease duration was 30 days or more (Table 2).
Manifestations on oral mucosa were found in 26 people, 54.2%. The frequency of oral mucosa lesions was higher in patients in the early stages of rehabilitation and whose disease duration exceeded 30 days (Table 3).
Conclusions:Post-COVID-19 patients had a high level of sIgA and BAPNA-amidase activity in saliva, while the level of neutrophil elastase activity is 10 times lower (p<0.001). A statistically significant decrease in sIgA level occurs during the rehabilitation period 3-6 months (p=0.006).
Lesions of the oral mucosa were more common in patients in the early stages of rehabilitation (1 month after COVID-19), as well as in patients whose disease duration exceeded 30 days, while in both cases there was a high level of sIgA in saliva.
Keyword(s): COVID-19, sIgA, salivaSession Type: ePosters
Session Title: ePosters
Authors(s): N. Kalchanava (1), B. Ferchichi (2)
Authors Affiliations(s): (1) Vitebsk State Order of Peoples’ Friendship Medical University, Belarus, (2) Minsk Research and Practice Center of surgery, transplantology and hematology, Belarus
Background:
COVID-19 primarily causes respiratory tract lesion. According to recent studies, patients may have ulcers, dry mouth, cracked lips or tongue, pinpoint hemorrhages, fungal infections of the oral cavity.
Purpose. To assess the state of local immunity of the oral cavity in patients after COVID-19.
Methods:The study involved 48 post-COVID-19 patients and on 28 healthy people. Saliva was used as a biological material, in which the level of sIgA (Saliva ELISA kit, Euroimmun, Germany), elastase, and BAPNA-amidase activity (Sigma-Aldrich, USA) was determined.
Results:The amount of sIgA in saliva in patients during the rehabilitation period after COVID-19 was 592.67; 254.23-944.39 μg/ml, which is higher than in the control group (p<0.05).
Depending on the timing of the disease, patients with COVID-19 showed a statistically significant increase in sIgA values after 7 days and increased up to 30 days from the start of treatment (Table 1).
The level of neutrophil elastase activity in saliva was lower in patients after COVID-19 (9.1×10-5; 0.7×10-5-42.3×10-5 pkat) than that in the control group 90×10-5; 20×10-5-13×10-5 pkat (p<0.001).
The level of BAPNA-amidase activity did not differ from the control group (p>0.05). In the control group, this indicator was 2.6; 1.59-3.79 pkat, whereas in patients with COVID-19 the values were 2.9; 1.46-3.99 pkat. When analyzing this data over time, it was found that BAPNA-amidase activity increases in patients whose disease duration was 30 days or more (Table 2).
Manifestations on oral mucosa were found in 26 people, 54.2%. The frequency of oral mucosa lesions was higher in patients in the early stages of rehabilitation and whose disease duration exceeded 30 days (Table 3).
Conclusions:Post-COVID-19 patients had a high level of sIgA and BAPNA-amidase activity in saliva, while the level of neutrophil elastase activity is 10 times lower (p<0.001). A statistically significant decrease in sIgA level occurs during the rehabilitation period 3-6 months (p=0.006).
Lesions of the oral mucosa were more common in patients in the early stages of rehabilitation (1 month after COVID-19), as well as in patients whose disease duration exceeded 30 days, while in both cases there was a high level of sIgA in saliva.
Keyword(s): COVID-19, sIgA, saliva