Session Type: ePosters
Session Title: ePosters
Authors(s): S.M. Jazayeri (1), I. Sedighi (2), A. Fahimzad (3), A. Ghaziasadi (1), A. Tavakoli (4)
Authors Affiliations(s): (1) Research Center For Clinical Virology, Tehran University of Medical Sciences, Tehran, Iran, Iran, Islamic Republic of, (2) Department of Pediatric, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran, Iran, Islamic Republic of, (3) Pediatric Infectious Diseases Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran, Iran, Islamic Republic of, (4) . Research Center of Pediatric Infectious Diseases, Institute of Immunology and Infectious Diseases, Iran University of Medical Sciences, Tehran, Iran, Iran, Islamic Republic of
Third Party Affiliation: Research Center For Clinical Virology, Tehran University of Medical Sciences, Tehran, IranDepartment of Pediatric, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, IranPediatric Infectious Diseases Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IranResearch Center For Clinical Virology, Tehran University of Medical Sciences, Tehran, IranResearch Center of Pediatric Infectious Diseases, Institute of Immunology and Infectious Diseases, Iran University of Medical Sciences, Tehran, Iran
Background:
The objectives of this study were to analyze the clinical features and laboratory profiles and risk factors associated with critical illness of children with SARS-CoV-2.
Methods:325 COVID-19 Iranian pediatric patients were recruited through a collaborative research network between March and May 2020. Demographics, clinical, laboratory, and radiological results were obtained from patient files
Results:Of 325 patients, 189 (58.1%) and 136 (41.8%) were males and females, respectively. The mean age was 6.18 ± 4.99. 195 (60%) and 130 (40%), had moderate and severe conditions, respectively. 45 (13.9%) of patients died. The common symptoms were fever (72.6%), cough (59%) and shortness of breath (36%). 254 (78%) and 145 (44.6%( had gastrointestinal and neurological symptoms, respectively. Shortness of breath, rhinorrhea, nausea/vomiting, decrease in platelet counts; increase values in C-reactive protein, lactate dehydrogenase (LDH), and blood urea nitrogen, decrease in the blood PH and HCO3 were significantly associated with the disease severity. 58.1% and 65.3% of patients showed abnormal radiographic appearance in Chest X-ray and in chest CT scan, respectively, which were correlated with disease severity. 104 (32%) of patients referred to ICU. The coexistence of comorbidity was the main factor associated with ICU admission, shock, arrhythmia, acute kidney injury, acute respiratory distress syndrome (ARDS), acute cardiac injury, and death.
Conclusions:We describe a higher than previously recognized rate of COVID-19 mortality in Iranian pediatric patients. Epidemiological factors, such as relatively high case fatality rate in the country and the presence of underlying diseases were the main factors for the high death rate.
Keyword(s): Severe Acute Respiratory Syndrome Coronavirus-2, COVID-19, ChildrenSession Type: ePosters
Session Title: ePosters
Authors(s): S.M. Jazayeri (1), I. Sedighi (2), A. Fahimzad (3), A. Ghaziasadi (1), A. Tavakoli (4)
Authors Affiliations(s): (1) Research Center For Clinical Virology, Tehran University of Medical Sciences, Tehran, Iran, Iran, Islamic Republic of, (2) Department of Pediatric, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran, Iran, Islamic Republic of, (3) Pediatric Infectious Diseases Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran, Iran, Islamic Republic of, (4) . Research Center of Pediatric Infectious Diseases, Institute of Immunology and Infectious Diseases, Iran University of Medical Sciences, Tehran, Iran, Iran, Islamic Republic of
Third Party Affiliation: Research Center For Clinical Virology, Tehran University of Medical Sciences, Tehran, IranDepartment of Pediatric, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, IranPediatric Infectious Diseases Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IranResearch Center For Clinical Virology, Tehran University of Medical Sciences, Tehran, IranResearch Center of Pediatric Infectious Diseases, Institute of Immunology and Infectious Diseases, Iran University of Medical Sciences, Tehran, Iran
Background:
The objectives of this study were to analyze the clinical features and laboratory profiles and risk factors associated with critical illness of children with SARS-CoV-2.
Methods:325 COVID-19 Iranian pediatric patients were recruited through a collaborative research network between March and May 2020. Demographics, clinical, laboratory, and radiological results were obtained from patient files
Results:Of 325 patients, 189 (58.1%) and 136 (41.8%) were males and females, respectively. The mean age was 6.18 ± 4.99. 195 (60%) and 130 (40%), had moderate and severe conditions, respectively. 45 (13.9%) of patients died. The common symptoms were fever (72.6%), cough (59%) and shortness of breath (36%). 254 (78%) and 145 (44.6%( had gastrointestinal and neurological symptoms, respectively. Shortness of breath, rhinorrhea, nausea/vomiting, decrease in platelet counts; increase values in C-reactive protein, lactate dehydrogenase (LDH), and blood urea nitrogen, decrease in the blood PH and HCO3 were significantly associated with the disease severity. 58.1% and 65.3% of patients showed abnormal radiographic appearance in Chest X-ray and in chest CT scan, respectively, which were correlated with disease severity. 104 (32%) of patients referred to ICU. The coexistence of comorbidity was the main factor associated with ICU admission, shock, arrhythmia, acute kidney injury, acute respiratory distress syndrome (ARDS), acute cardiac injury, and death.
Conclusions:We describe a higher than previously recognized rate of COVID-19 mortality in Iranian pediatric patients. Epidemiological factors, such as relatively high case fatality rate in the country and the presence of underlying diseases were the main factors for the high death rate.
Keyword(s): Severe Acute Respiratory Syndrome Coronavirus-2, COVID-19, Children