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Session Type: ePosters
Session Title: ePosters
Authors(s): J. Liu, S. Xu, Y. An, X. Wei, H. Yi
Authors Affiliations(s): The Third Affiliated Hospital of Sun Yat-sen University, China
Background:
Donor - derived pathogen infection is a topic that the organ transplant industry will never avoided, because donors undergo invasive procedures and ICU treatment for a period of time before donation, and become carriers of various pathogens during this period. This paper introduces a new method of liver perfusion combined with imipenem and tigecycline, which was first used by our center, to significantly reduce the incidence of receptor infection after transplantation.
Methods:A retrospective analysis was made on Whole liver transplantation patients in our hospital from January 2017 to December 2018. Split liver transplantation, parental liver transplantation and Postoperative death due to non-infectious factors are excluded .Among them, 79 livers were perfused with UW solution 1000ml added with Gentamicin Sulfate 80000 U (UW-GS). 193 livers were perfused with UW solution 1000ml added with imipenem 1g and tigecycline 50mg (UW-IMI/TIG).The results of organ preservation solution before and after liver perfusion and microbial culture of recipient after transplantation were compared.
Results:There was no difference in the positive rate of microorganism culture before organ perfusion between UW-IMI/TIG and UW-GS groups (9.8% VS 10.1%), including drug-resistant Acinetobacter baumannii (2.59% VS 3.80%) and drug-resistant Klebsiella pneumoniae (3.11% VS 2.53%) and Candida (1.55% VS 2.5%).After perfusion, the positive rate of microorganism in the perfusion fluid of both groups decreased significantly (2.07% VS 9.8%, 3.80%VS10.1%). The positive rate of drug-resistant bacteria also decreased significantly, such as drug-resistant Acinetobacter baumannii (0.518%VS2.59%, 2.53%VS3.80%) and drug-resistant Klebsiella pneumoniae (1.27%VS3.11%, 0.518%VS 2.53%). After perfusion, the positive rate of microorganism in the perfusion fluid of the UW-IMI/TIG group was significantly lower than that of the UW-GS group.After transplantation, the pathogen infection rate of transplant recipients in the UW-IMI/TIG group was significantly lower than that in the UW-GS group (19.2% VS 62%), and the infection rate of drug-resistant bacteria in the UW-IMI/TIG group was also lower, such as drug-resistant Acinetobacter baumannii (1.55% VS 8.86%) and drug-resistant Klebsiella pneumoniae (2.59% VS3.80%).
Conclusions:Liver perfusion with tigecycline and imipenem during liver repair can effectively reduce donor-derived pathogenic bacteria, reduce the infection rate after recipient transplantation, and facilitate the smooth recovery of recipient after surgery.
Keyword(s): Organ donation, liver transplantation, Donor - derived infectionSession Type: ePosters
Session Title: ePosters
Authors(s): J. Liu, S. Xu, Y. An, X. Wei, H. Yi
Authors Affiliations(s): The Third Affiliated Hospital of Sun Yat-sen University, China
Background:
Donor - derived pathogen infection is a topic that the organ transplant industry will never avoided, because donors undergo invasive procedures and ICU treatment for a period of time before donation, and become carriers of various pathogens during this period. This paper introduces a new method of liver perfusion combined with imipenem and tigecycline, which was first used by our center, to significantly reduce the incidence of receptor infection after transplantation.
Methods:A retrospective analysis was made on Whole liver transplantation patients in our hospital from January 2017 to December 2018. Split liver transplantation, parental liver transplantation and Postoperative death due to non-infectious factors are excluded .Among them, 79 livers were perfused with UW solution 1000ml added with Gentamicin Sulfate 80000 U (UW-GS). 193 livers were perfused with UW solution 1000ml added with imipenem 1g and tigecycline 50mg (UW-IMI/TIG).The results of organ preservation solution before and after liver perfusion and microbial culture of recipient after transplantation were compared.
Results:There was no difference in the positive rate of microorganism culture before organ perfusion between UW-IMI/TIG and UW-GS groups (9.8% VS 10.1%), including drug-resistant Acinetobacter baumannii (2.59% VS 3.80%) and drug-resistant Klebsiella pneumoniae (3.11% VS 2.53%) and Candida (1.55% VS 2.5%).After perfusion, the positive rate of microorganism in the perfusion fluid of both groups decreased significantly (2.07% VS 9.8%, 3.80%VS10.1%). The positive rate of drug-resistant bacteria also decreased significantly, such as drug-resistant Acinetobacter baumannii (0.518%VS2.59%, 2.53%VS3.80%) and drug-resistant Klebsiella pneumoniae (1.27%VS3.11%, 0.518%VS 2.53%). After perfusion, the positive rate of microorganism in the perfusion fluid of the UW-IMI/TIG group was significantly lower than that of the UW-GS group.After transplantation, the pathogen infection rate of transplant recipients in the UW-IMI/TIG group was significantly lower than that in the UW-GS group (19.2% VS 62%), and the infection rate of drug-resistant bacteria in the UW-IMI/TIG group was also lower, such as drug-resistant Acinetobacter baumannii (1.55% VS 8.86%) and drug-resistant Klebsiella pneumoniae (2.59% VS3.80%).
Conclusions:Liver perfusion with tigecycline and imipenem during liver repair can effectively reduce donor-derived pathogenic bacteria, reduce the infection rate after recipient transplantation, and facilitate the smooth recovery of recipient after surgery.
Keyword(s): Organ donation, liver transplantation, Donor - derived infection
Session Type: ePosters
Session Title: ePosters
Authors(s): J. Liu, S. Xu, Y. An, X. Wei, H. Yi
Authors Affiliations(s): The Third Affiliated Hospital of Sun Yat-sen University, China
Background:
Donor - derived pathogen infection is a topic that the organ transplant industry will never avoided, because donors undergo invasive procedures and ICU treatment for a period of time before donation, and become carriers of various pathogens during this period. This paper introduces a new method of liver perfusion combined with imipenem and tigecycline, which was first used by our center, to significantly reduce the incidence of receptor infection after transplantation.
Methods:A retrospective analysis was made on Whole liver transplantation patients in our hospital from January 2017 to December 2018. Split liver transplantation, parental liver transplantation and Postoperative death due to non-infectious factors are excluded .Among them, 79 livers were perfused with UW solution 1000ml added with Gentamicin Sulfate 80000 U (UW-GS). 193 livers were perfused with UW solution 1000ml added with imipenem 1g and tigecycline 50mg (UW-IMI/TIG).The results of organ preservation solution before and after liver perfusion and microbial culture of recipient after transplantation were compared.
Results:There was no difference in the positive rate of microorganism culture before organ perfusion between UW-IMI/TIG and UW-GS groups (9.8% VS 10.1%), including drug-resistant Acinetobacter baumannii (2.59% VS 3.80%) and drug-resistant Klebsiella pneumoniae (3.11% VS 2.53%) and Candida (1.55% VS 2.5%).After perfusion, the positive rate of microorganism in the perfusion fluid of both groups decreased significantly (2.07% VS 9.8%, 3.80%VS10.1%). The positive rate of drug-resistant bacteria also decreased significantly, such as drug-resistant Acinetobacter baumannii (0.518%VS2.59%, 2.53%VS3.80%) and drug-resistant Klebsiella pneumoniae (1.27%VS3.11%, 0.518%VS 2.53%). After perfusion, the positive rate of microorganism in the perfusion fluid of the UW-IMI/TIG group was significantly lower than that of the UW-GS group.After transplantation, the pathogen infection rate of transplant recipients in the UW-IMI/TIG group was significantly lower than that in the UW-GS group (19.2% VS 62%), and the infection rate of drug-resistant bacteria in the UW-IMI/TIG group was also lower, such as drug-resistant Acinetobacter baumannii (1.55% VS 8.86%) and drug-resistant Klebsiella pneumoniae (2.59% VS3.80%).
Conclusions:Liver perfusion with tigecycline and imipenem during liver repair can effectively reduce donor-derived pathogenic bacteria, reduce the infection rate after recipient transplantation, and facilitate the smooth recovery of recipient after surgery.
Keyword(s): Organ donation, liver transplantation, Donor - derived infectionSession Type: ePosters
Session Title: ePosters
Authors(s): J. Liu, S. Xu, Y. An, X. Wei, H. Yi
Authors Affiliations(s): The Third Affiliated Hospital of Sun Yat-sen University, China
Background:
Donor - derived pathogen infection is a topic that the organ transplant industry will never avoided, because donors undergo invasive procedures and ICU treatment for a period of time before donation, and become carriers of various pathogens during this period. This paper introduces a new method of liver perfusion combined with imipenem and tigecycline, which was first used by our center, to significantly reduce the incidence of receptor infection after transplantation.
Methods:A retrospective analysis was made on Whole liver transplantation patients in our hospital from January 2017 to December 2018. Split liver transplantation, parental liver transplantation and Postoperative death due to non-infectious factors are excluded .Among them, 79 livers were perfused with UW solution 1000ml added with Gentamicin Sulfate 80000 U (UW-GS). 193 livers were perfused with UW solution 1000ml added with imipenem 1g and tigecycline 50mg (UW-IMI/TIG).The results of organ preservation solution before and after liver perfusion and microbial culture of recipient after transplantation were compared.
Results:There was no difference in the positive rate of microorganism culture before organ perfusion between UW-IMI/TIG and UW-GS groups (9.8% VS 10.1%), including drug-resistant Acinetobacter baumannii (2.59% VS 3.80%) and drug-resistant Klebsiella pneumoniae (3.11% VS 2.53%) and Candida (1.55% VS 2.5%).After perfusion, the positive rate of microorganism in the perfusion fluid of both groups decreased significantly (2.07% VS 9.8%, 3.80%VS10.1%). The positive rate of drug-resistant bacteria also decreased significantly, such as drug-resistant Acinetobacter baumannii (0.518%VS2.59%, 2.53%VS3.80%) and drug-resistant Klebsiella pneumoniae (1.27%VS3.11%, 0.518%VS 2.53%). After perfusion, the positive rate of microorganism in the perfusion fluid of the UW-IMI/TIG group was significantly lower than that of the UW-GS group.After transplantation, the pathogen infection rate of transplant recipients in the UW-IMI/TIG group was significantly lower than that in the UW-GS group (19.2% VS 62%), and the infection rate of drug-resistant bacteria in the UW-IMI/TIG group was also lower, such as drug-resistant Acinetobacter baumannii (1.55% VS 8.86%) and drug-resistant Klebsiella pneumoniae (2.59% VS3.80%).
Conclusions:Liver perfusion with tigecycline and imipenem during liver repair can effectively reduce donor-derived pathogenic bacteria, reduce the infection rate after recipient transplantation, and facilitate the smooth recovery of recipient after surgery.
Keyword(s): Organ donation, liver transplantation, Donor - derived infection