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Abstract
Discussion Forum (0)
Abstract number: 1185

Session Type: ePosters

Session Title: ePosters

Authors(s): D. Matranga (1), M. Enea (1), L. Maniscalco (1), F. Provenzano (2), V. Provenzano (2), P. Di Carlo (1)

Authors Affiliations(s): (1) PROMISE Dep, University of Palermo, Italy, (2) Partinico COVID Hospital, Italy

Background:

Elderly subjects with SARS-Covid 2 infection need to be considered more vulnerable than other population for underlying medical comorbidities especially mental disorders. To improve the management of SARS CoV-2 infection in elderly population, we analyzed the mortality risk related to epidemiological risk factors, underlining disease and clinical course by daily follow-up of clinical and laboratory findings during the early wave of the pandemic

Methods:

We performed a retrospective longitudinal monocentric cohort study of adult Italian patients admitted for SARS-CoV2 infection at Partinico COVID Hospital in the province of Palermo (Sicily, South-Italy) between 4 March and 25 April and followed-up until 31st May 2020. Patients were followed up daily until death or hospital discharge. The criterion for discharge was the occurrence of two consecutive nasal and pharyngeal swabs, at a distance of at least 24-hours, negative for SARS-CoV-2 RNA.

Results:

From the beginning of March, there were 47 patients followed up for a total of 87 days, which contributed 1,035 person-days of observation.  The patients’ median age was 75 (IQR= 59.50 - 86.00). The recorded underlying medical conditions showed dementia in 10 (21%) patients (median age 85.50, IQR = 79 - 92.75) and mental disorders in 6 (12%) patients (median age 66.50, IQR =61-83.25). Diabetes (HR 8.13, 95%CI=[1.91 - 34.67]),  chronic kidney failure (CRF) (HR 5.86, 95%CI=[1.36-25.21]) and dementia (HR 7.84, 95%CI=[1.80-34.20]) were found significant risk factors. The Neutrophils/Lymphocytes Ratio>7 (HR 10.37, 95%CI=[2.24 - 48.14]) resulted a significant prognostic factor

Conclusions:

Our study encourages to processing clinical and laboratory data with statistical methods that consider a daily evaluation in elderly to focus on prognostic indicators after hospitalization Among laboratory parameters Neutrophils/Lymphocytes Ratio showed an optimal prognostic value already in the first week of follow-up  In conclusion,  the in-depth knowledge of complete clinical course and therefore the follow-up of the clinical and laboratory parameters of the disease could help the home management of patient with dementia and diabetes. To the best management of these patients, it should be appropriate including in SARS COV 2 team working also endocrinologist and geriatric specialists

Keyword(s): elderly, diabetes, dementia

Abstract number: 1185

Session Type: ePosters

Session Title: ePosters

Authors(s): D. Matranga (1), M. Enea (1), L. Maniscalco (1), F. Provenzano (2), V. Provenzano (2), P. Di Carlo (1)

Authors Affiliations(s): (1) PROMISE Dep, University of Palermo, Italy, (2) Partinico COVID Hospital, Italy

Background:

Elderly subjects with SARS-Covid 2 infection need to be considered more vulnerable than other population for underlying medical comorbidities especially mental disorders. To improve the management of SARS CoV-2 infection in elderly population, we analyzed the mortality risk related to epidemiological risk factors, underlining disease and clinical course by daily follow-up of clinical and laboratory findings during the early wave of the pandemic

Methods:

We performed a retrospective longitudinal monocentric cohort study of adult Italian patients admitted for SARS-CoV2 infection at Partinico COVID Hospital in the province of Palermo (Sicily, South-Italy) between 4 March and 25 April and followed-up until 31st May 2020. Patients were followed up daily until death or hospital discharge. The criterion for discharge was the occurrence of two consecutive nasal and pharyngeal swabs, at a distance of at least 24-hours, negative for SARS-CoV-2 RNA.

Results:

From the beginning of March, there were 47 patients followed up for a total of 87 days, which contributed 1,035 person-days of observation.  The patients’ median age was 75 (IQR= 59.50 - 86.00). The recorded underlying medical conditions showed dementia in 10 (21%) patients (median age 85.50, IQR = 79 - 92.75) and mental disorders in 6 (12%) patients (median age 66.50, IQR =61-83.25). Diabetes (HR 8.13, 95%CI=[1.91 - 34.67]),  chronic kidney failure (CRF) (HR 5.86, 95%CI=[1.36-25.21]) and dementia (HR 7.84, 95%CI=[1.80-34.20]) were found significant risk factors. The Neutrophils/Lymphocytes Ratio>7 (HR 10.37, 95%CI=[2.24 - 48.14]) resulted a significant prognostic factor

Conclusions:

Our study encourages to processing clinical and laboratory data with statistical methods that consider a daily evaluation in elderly to focus on prognostic indicators after hospitalization Among laboratory parameters Neutrophils/Lymphocytes Ratio showed an optimal prognostic value already in the first week of follow-up  In conclusion,  the in-depth knowledge of complete clinical course and therefore the follow-up of the clinical and laboratory parameters of the disease could help the home management of patient with dementia and diabetes. To the best management of these patients, it should be appropriate including in SARS COV 2 team working also endocrinologist and geriatric specialists

Keyword(s): elderly, diabetes, dementia

SARS-CoV-2 disease in older hospitalised patients in Southern Italy by day-to-day follow-up
Assoc. Prof. Paola Di Carlo
Assoc. Prof. Paola Di Carlo
ESCMID eAcademy. Di Carlo P. 07/09/2021; 328012; 1185;
user
Assoc. Prof. Paola Di Carlo
Abstract
Discussion Forum (0)
Abstract number: 1185

Session Type: ePosters

Session Title: ePosters

Authors(s): D. Matranga (1), M. Enea (1), L. Maniscalco (1), F. Provenzano (2), V. Provenzano (2), P. Di Carlo (1)

Authors Affiliations(s): (1) PROMISE Dep, University of Palermo, Italy, (2) Partinico COVID Hospital, Italy

Background:

Elderly subjects with SARS-Covid 2 infection need to be considered more vulnerable than other population for underlying medical comorbidities especially mental disorders. To improve the management of SARS CoV-2 infection in elderly population, we analyzed the mortality risk related to epidemiological risk factors, underlining disease and clinical course by daily follow-up of clinical and laboratory findings during the early wave of the pandemic

Methods:

We performed a retrospective longitudinal monocentric cohort study of adult Italian patients admitted for SARS-CoV2 infection at Partinico COVID Hospital in the province of Palermo (Sicily, South-Italy) between 4 March and 25 April and followed-up until 31st May 2020. Patients were followed up daily until death or hospital discharge. The criterion for discharge was the occurrence of two consecutive nasal and pharyngeal swabs, at a distance of at least 24-hours, negative for SARS-CoV-2 RNA.

Results:

From the beginning of March, there were 47 patients followed up for a total of 87 days, which contributed 1,035 person-days of observation.  The patients’ median age was 75 (IQR= 59.50 - 86.00). The recorded underlying medical conditions showed dementia in 10 (21%) patients (median age 85.50, IQR = 79 - 92.75) and mental disorders in 6 (12%) patients (median age 66.50, IQR =61-83.25). Diabetes (HR 8.13, 95%CI=[1.91 - 34.67]),  chronic kidney failure (CRF) (HR 5.86, 95%CI=[1.36-25.21]) and dementia (HR 7.84, 95%CI=[1.80-34.20]) were found significant risk factors. The Neutrophils/Lymphocytes Ratio>7 (HR 10.37, 95%CI=[2.24 - 48.14]) resulted a significant prognostic factor

Conclusions:

Our study encourages to processing clinical and laboratory data with statistical methods that consider a daily evaluation in elderly to focus on prognostic indicators after hospitalization Among laboratory parameters Neutrophils/Lymphocytes Ratio showed an optimal prognostic value already in the first week of follow-up  In conclusion,  the in-depth knowledge of complete clinical course and therefore the follow-up of the clinical and laboratory parameters of the disease could help the home management of patient with dementia and diabetes. To the best management of these patients, it should be appropriate including in SARS COV 2 team working also endocrinologist and geriatric specialists

Keyword(s): elderly, diabetes, dementia

Abstract number: 1185

Session Type: ePosters

Session Title: ePosters

Authors(s): D. Matranga (1), M. Enea (1), L. Maniscalco (1), F. Provenzano (2), V. Provenzano (2), P. Di Carlo (1)

Authors Affiliations(s): (1) PROMISE Dep, University of Palermo, Italy, (2) Partinico COVID Hospital, Italy

Background:

Elderly subjects with SARS-Covid 2 infection need to be considered more vulnerable than other population for underlying medical comorbidities especially mental disorders. To improve the management of SARS CoV-2 infection in elderly population, we analyzed the mortality risk related to epidemiological risk factors, underlining disease and clinical course by daily follow-up of clinical and laboratory findings during the early wave of the pandemic

Methods:

We performed a retrospective longitudinal monocentric cohort study of adult Italian patients admitted for SARS-CoV2 infection at Partinico COVID Hospital in the province of Palermo (Sicily, South-Italy) between 4 March and 25 April and followed-up until 31st May 2020. Patients were followed up daily until death or hospital discharge. The criterion for discharge was the occurrence of two consecutive nasal and pharyngeal swabs, at a distance of at least 24-hours, negative for SARS-CoV-2 RNA.

Results:

From the beginning of March, there were 47 patients followed up for a total of 87 days, which contributed 1,035 person-days of observation.  The patients’ median age was 75 (IQR= 59.50 - 86.00). The recorded underlying medical conditions showed dementia in 10 (21%) patients (median age 85.50, IQR = 79 - 92.75) and mental disorders in 6 (12%) patients (median age 66.50, IQR =61-83.25). Diabetes (HR 8.13, 95%CI=[1.91 - 34.67]),  chronic kidney failure (CRF) (HR 5.86, 95%CI=[1.36-25.21]) and dementia (HR 7.84, 95%CI=[1.80-34.20]) were found significant risk factors. The Neutrophils/Lymphocytes Ratio>7 (HR 10.37, 95%CI=[2.24 - 48.14]) resulted a significant prognostic factor

Conclusions:

Our study encourages to processing clinical and laboratory data with statistical methods that consider a daily evaluation in elderly to focus on prognostic indicators after hospitalization Among laboratory parameters Neutrophils/Lymphocytes Ratio showed an optimal prognostic value already in the first week of follow-up  In conclusion,  the in-depth knowledge of complete clinical course and therefore the follow-up of the clinical and laboratory parameters of the disease could help the home management of patient with dementia and diabetes. To the best management of these patients, it should be appropriate including in SARS COV 2 team working also endocrinologist and geriatric specialists

Keyword(s): elderly, diabetes, dementia

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