Session Type: ePosters
Session Title: ePosters
Authors(s): S. Bourassa-Blachette, J. Lam, A. Kipp, J. Carson, M. Parkins, D. Church, D. Gregson
Authors Affiliations(s): University of Calgary, Canada
Background:
Candidemia is reported to be increasing in frequency and associated with high mortality. We sought to determine the outcomes, and impact of infectious disease consultation in candidemic patients in our region.
Methods:Data on adult patients with positive blood cultures from January 1, 2010, to December 31, 2018, for any Candida spp. was extracted from the laboratory and linked with the provincial patient information system to obtain data on survival (14, 30, 90, and 365 days) and underlying diseases. The electronic chart (Sunrise Clinical Manager, SCM) was reviewed to determine other aspects of management and if IDC was performed. Patients with repeat cultures with the same species of Candida, who died within 5 days of admission, and who were admitted to rural hospitals were excluded from the analysis. Differences in dichotomous outcomes were determined using chi-squared analysis with Yates correction.
Results:There were 445 cases of candidemia during the study with no trend for increasing numbers. The average age of the patients was 58 years and 221 (48%) were female. C. albicans was the most common species followed by C. glabrata. These two species constituted 74% of all cases. No other species accounting for more than 7% of cases (see figure 1). Overall mortality at 14, 30, 90, and 365 days was 27%, 35.5%, 42.9%, and 50.8% respectively. Thirty-day mortality was higher for patients with C. albicans, C. dubliniensis, and C. glabrata (37.6%) compared to C. guilliermondi, C. lusitaniae, C. parapsilosis, and C. tropicalis (21.3%, P = 0.01). IDC was obtained in 65% of all cases. Death was more common in patients without (91/166) than in those with (78/290) IDC (P < 0.00001). IDC was obtained more frequently in the last 3 years of the study (68% vs 52%, P < 0.01)
Conclusions:In our region, the incidence of Candidemia is not increasing. C. albicans was the most common species. The mortality was high with half of the patients dying in the year following an episode of Candidemia. IDC was associated with lower mortality and was obtained more frequently in the last 3 years of the study.
Keyword(s): Candidemia, Outcomes, MortalityCOI Institutional Grants: Yes COI Stock Options: Yes
Session Type: ePosters
Session Title: ePosters
Authors(s): S. Bourassa-Blachette, J. Lam, A. Kipp, J. Carson, M. Parkins, D. Church, D. Gregson
Authors Affiliations(s): University of Calgary, Canada
Background:
Candidemia is reported to be increasing in frequency and associated with high mortality. We sought to determine the outcomes, and impact of infectious disease consultation in candidemic patients in our region.
Methods:Data on adult patients with positive blood cultures from January 1, 2010, to December 31, 2018, for any Candida spp. was extracted from the laboratory and linked with the provincial patient information system to obtain data on survival (14, 30, 90, and 365 days) and underlying diseases. The electronic chart (Sunrise Clinical Manager, SCM) was reviewed to determine other aspects of management and if IDC was performed. Patients with repeat cultures with the same species of Candida, who died within 5 days of admission, and who were admitted to rural hospitals were excluded from the analysis. Differences in dichotomous outcomes were determined using chi-squared analysis with Yates correction.
Results:There were 445 cases of candidemia during the study with no trend for increasing numbers. The average age of the patients was 58 years and 221 (48%) were female. C. albicans was the most common species followed by C. glabrata. These two species constituted 74% of all cases. No other species accounting for more than 7% of cases (see figure 1). Overall mortality at 14, 30, 90, and 365 days was 27%, 35.5%, 42.9%, and 50.8% respectively. Thirty-day mortality was higher for patients with C. albicans, C. dubliniensis, and C. glabrata (37.6%) compared to C. guilliermondi, C. lusitaniae, C. parapsilosis, and C. tropicalis (21.3%, P = 0.01). IDC was obtained in 65% of all cases. Death was more common in patients without (91/166) than in those with (78/290) IDC (P < 0.00001). IDC was obtained more frequently in the last 3 years of the study (68% vs 52%, P < 0.01)
Conclusions:In our region, the incidence of Candidemia is not increasing. C. albicans was the most common species. The mortality was high with half of the patients dying in the year following an episode of Candidemia. IDC was associated with lower mortality and was obtained more frequently in the last 3 years of the study.
Keyword(s): Candidemia, Outcomes, MortalityCOI Institutional Grants: Yes COI Stock Options: Yes
Session Type: ePosters
Session Title: ePosters
Authors(s): S. Bourassa-Blachette, J. Lam, A. Kipp, J. Carson, M. Parkins, D. Church, D. Gregson
Authors Affiliations(s): University of Calgary, Canada
Background:
Candidemia is reported to be increasing in frequency and associated with high mortality. We sought to determine the outcomes, and impact of infectious disease consultation in candidemic patients in our region.
Methods:Data on adult patients with positive blood cultures from January 1, 2010, to December 31, 2018, for any Candida spp. was extracted from the laboratory and linked with the provincial patient information system to obtain data on survival (14, 30, 90, and 365 days) and underlying diseases. The electronic chart (Sunrise Clinical Manager, SCM) was reviewed to determine other aspects of management and if IDC was performed. Patients with repeat cultures with the same species of Candida, who died within 5 days of admission, and who were admitted to rural hospitals were excluded from the analysis. Differences in dichotomous outcomes were determined using chi-squared analysis with Yates correction.
Results:There were 445 cases of candidemia during the study with no trend for increasing numbers. The average age of the patients was 58 years and 221 (48%) were female. C. albicans was the most common species followed by C. glabrata. These two species constituted 74% of all cases. No other species accounting for more than 7% of cases (see figure 1). Overall mortality at 14, 30, 90, and 365 days was 27%, 35.5%, 42.9%, and 50.8% respectively. Thirty-day mortality was higher for patients with C. albicans, C. dubliniensis, and C. glabrata (37.6%) compared to C. guilliermondi, C. lusitaniae, C. parapsilosis, and C. tropicalis (21.3%, P = 0.01). IDC was obtained in 65% of all cases. Death was more common in patients without (91/166) than in those with (78/290) IDC (P < 0.00001). IDC was obtained more frequently in the last 3 years of the study (68% vs 52%, P < 0.01)
Conclusions:In our region, the incidence of Candidemia is not increasing. C. albicans was the most common species. The mortality was high with half of the patients dying in the year following an episode of Candidemia. IDC was associated with lower mortality and was obtained more frequently in the last 3 years of the study.
Keyword(s): Candidemia, Outcomes, MortalityCOI Institutional Grants: Yes COI Stock Options: Yes
Session Type: ePosters
Session Title: ePosters
Authors(s): S. Bourassa-Blachette, J. Lam, A. Kipp, J. Carson, M. Parkins, D. Church, D. Gregson
Authors Affiliations(s): University of Calgary, Canada
Background:
Candidemia is reported to be increasing in frequency and associated with high mortality. We sought to determine the outcomes, and impact of infectious disease consultation in candidemic patients in our region.
Methods:Data on adult patients with positive blood cultures from January 1, 2010, to December 31, 2018, for any Candida spp. was extracted from the laboratory and linked with the provincial patient information system to obtain data on survival (14, 30, 90, and 365 days) and underlying diseases. The electronic chart (Sunrise Clinical Manager, SCM) was reviewed to determine other aspects of management and if IDC was performed. Patients with repeat cultures with the same species of Candida, who died within 5 days of admission, and who were admitted to rural hospitals were excluded from the analysis. Differences in dichotomous outcomes were determined using chi-squared analysis with Yates correction.
Results:There were 445 cases of candidemia during the study with no trend for increasing numbers. The average age of the patients was 58 years and 221 (48%) were female. C. albicans was the most common species followed by C. glabrata. These two species constituted 74% of all cases. No other species accounting for more than 7% of cases (see figure 1). Overall mortality at 14, 30, 90, and 365 days was 27%, 35.5%, 42.9%, and 50.8% respectively. Thirty-day mortality was higher for patients with C. albicans, C. dubliniensis, and C. glabrata (37.6%) compared to C. guilliermondi, C. lusitaniae, C. parapsilosis, and C. tropicalis (21.3%, P = 0.01). IDC was obtained in 65% of all cases. Death was more common in patients without (91/166) than in those with (78/290) IDC (P < 0.00001). IDC was obtained more frequently in the last 3 years of the study (68% vs 52%, P < 0.01)
Conclusions:In our region, the incidence of Candidemia is not increasing. C. albicans was the most common species. The mortality was high with half of the patients dying in the year following an episode of Candidemia. IDC was associated with lower mortality and was obtained more frequently in the last 3 years of the study.
Keyword(s): Candidemia, Outcomes, MortalityCOI Institutional Grants: Yes COI Stock Options: Yes