Session Type: ePosters
Session Title: ePosters
Authors(s): M.A. Füller (1), S. Kampmeier (2), A.M. Wübbolding (1), J. Grönefeld (1), A. Kremer (3), A.H. Groll (1)
Authors Affiliations(s): (1) Infectious Disease Research Program, Center for Bone Marrow Transplantation and Department of Pediatric Hematology and Oncology, University Children’s Hospital Muenster, Germany, (2) Department of Medical Microbiology, University Hospital Münster, Germany, (3) Medical Controlling, University Hospital Münster, Germany
Background:
Children and adolescents undergoing treatment for cancer or allogeneic hematopoietic stem cell transplantation (HSCT) are at increased risk for colonization and infection by Methicillin-resistant Staphylococcus aureus (MRSA), and control of MRSA in this setting is of particular importance. We therefore examined the occurrence and outcome of MRSA colonization and infection in children and adolescents with cancer or allogeneic HSCT in a large European pediatric cancer center with an established management bundle.
Methods:In a prospective single-center observational cohort study conducted between 2007 and 2018, nasopharyngeal swabs for culture of MRSA were obtained from all inpatient admissions to the pediatric Oncology and HSCT wards. The primary endpoint of the study was the colonization rate over time. Secondary endpoints included antibiotic resistance patterns, clonal relationships tested by genotyping technologies, time burden of isolation measures, implementation and results of decolonization efforts. Occurrence of invasive MRSA infections was also assessed.
Results:MRSA-screening identified 34 colonized patients (median age: 11 years; range: 0-21 years) without trends over time. MRSA colonization was associated with the presence of central venous catheters (76 %), immigration background (32 %), antibacterial treatment in the previous 4 weeks (53 %), status post surgery (41 %) and previous allogeneic HSCT (32 %). There was no molecular evidence of patient-to-patient transmission. Standard MRSA eradication regimen led to a lasting eradication of the organism in 24 of 34 patients. There was a total of two patients with MRSA infection during the 12 years observation period and no mortality from MRSA.
Conclusions:Prospective monitoring revealed low rates of MRSA colonization and infection at our center. These low rates and the absence of patient-to-patient transmission support the effectiveness of the managment bundle of MRSA identification, isolation, and decolonization.
Keyword(s): MRSA, Children, CancerSession Type: ePosters
Session Title: ePosters
Authors(s): M.A. Füller (1), S. Kampmeier (2), A.M. Wübbolding (1), J. Grönefeld (1), A. Kremer (3), A.H. Groll (1)
Authors Affiliations(s): (1) Infectious Disease Research Program, Center for Bone Marrow Transplantation and Department of Pediatric Hematology and Oncology, University Children’s Hospital Muenster, Germany, (2) Department of Medical Microbiology, University Hospital Münster, Germany, (3) Medical Controlling, University Hospital Münster, Germany
Background:
Children and adolescents undergoing treatment for cancer or allogeneic hematopoietic stem cell transplantation (HSCT) are at increased risk for colonization and infection by Methicillin-resistant Staphylococcus aureus (MRSA), and control of MRSA in this setting is of particular importance. We therefore examined the occurrence and outcome of MRSA colonization and infection in children and adolescents with cancer or allogeneic HSCT in a large European pediatric cancer center with an established management bundle.
Methods:In a prospective single-center observational cohort study conducted between 2007 and 2018, nasopharyngeal swabs for culture of MRSA were obtained from all inpatient admissions to the pediatric Oncology and HSCT wards. The primary endpoint of the study was the colonization rate over time. Secondary endpoints included antibiotic resistance patterns, clonal relationships tested by genotyping technologies, time burden of isolation measures, implementation and results of decolonization efforts. Occurrence of invasive MRSA infections was also assessed.
Results:MRSA-screening identified 34 colonized patients (median age: 11 years; range: 0-21 years) without trends over time. MRSA colonization was associated with the presence of central venous catheters (76 %), immigration background (32 %), antibacterial treatment in the previous 4 weeks (53 %), status post surgery (41 %) and previous allogeneic HSCT (32 %). There was no molecular evidence of patient-to-patient transmission. Standard MRSA eradication regimen led to a lasting eradication of the organism in 24 of 34 patients. There was a total of two patients with MRSA infection during the 12 years observation period and no mortality from MRSA.
Conclusions:Prospective monitoring revealed low rates of MRSA colonization and infection at our center. These low rates and the absence of patient-to-patient transmission support the effectiveness of the managment bundle of MRSA identification, isolation, and decolonization.
Keyword(s): MRSA, Children, Cancer
Session Type: ePosters
Session Title: ePosters
Authors(s): M.A. Füller (1), S. Kampmeier (2), A.M. Wübbolding (1), J. Grönefeld (1), A. Kremer (3), A.H. Groll (1)
Authors Affiliations(s): (1) Infectious Disease Research Program, Center for Bone Marrow Transplantation and Department of Pediatric Hematology and Oncology, University Children’s Hospital Muenster, Germany, (2) Department of Medical Microbiology, University Hospital Münster, Germany, (3) Medical Controlling, University Hospital Münster, Germany
Background:
Children and adolescents undergoing treatment for cancer or allogeneic hematopoietic stem cell transplantation (HSCT) are at increased risk for colonization and infection by Methicillin-resistant Staphylococcus aureus (MRSA), and control of MRSA in this setting is of particular importance. We therefore examined the occurrence and outcome of MRSA colonization and infection in children and adolescents with cancer or allogeneic HSCT in a large European pediatric cancer center with an established management bundle.
Methods:In a prospective single-center observational cohort study conducted between 2007 and 2018, nasopharyngeal swabs for culture of MRSA were obtained from all inpatient admissions to the pediatric Oncology and HSCT wards. The primary endpoint of the study was the colonization rate over time. Secondary endpoints included antibiotic resistance patterns, clonal relationships tested by genotyping technologies, time burden of isolation measures, implementation and results of decolonization efforts. Occurrence of invasive MRSA infections was also assessed.
Results:MRSA-screening identified 34 colonized patients (median age: 11 years; range: 0-21 years) without trends over time. MRSA colonization was associated with the presence of central venous catheters (76 %), immigration background (32 %), antibacterial treatment in the previous 4 weeks (53 %), status post surgery (41 %) and previous allogeneic HSCT (32 %). There was no molecular evidence of patient-to-patient transmission. Standard MRSA eradication regimen led to a lasting eradication of the organism in 24 of 34 patients. There was a total of two patients with MRSA infection during the 12 years observation period and no mortality from MRSA.
Conclusions:Prospective monitoring revealed low rates of MRSA colonization and infection at our center. These low rates and the absence of patient-to-patient transmission support the effectiveness of the managment bundle of MRSA identification, isolation, and decolonization.
Keyword(s): MRSA, Children, CancerSession Type: ePosters
Session Title: ePosters
Authors(s): M.A. Füller (1), S. Kampmeier (2), A.M. Wübbolding (1), J. Grönefeld (1), A. Kremer (3), A.H. Groll (1)
Authors Affiliations(s): (1) Infectious Disease Research Program, Center for Bone Marrow Transplantation and Department of Pediatric Hematology and Oncology, University Children’s Hospital Muenster, Germany, (2) Department of Medical Microbiology, University Hospital Münster, Germany, (3) Medical Controlling, University Hospital Münster, Germany
Background:
Children and adolescents undergoing treatment for cancer or allogeneic hematopoietic stem cell transplantation (HSCT) are at increased risk for colonization and infection by Methicillin-resistant Staphylococcus aureus (MRSA), and control of MRSA in this setting is of particular importance. We therefore examined the occurrence and outcome of MRSA colonization and infection in children and adolescents with cancer or allogeneic HSCT in a large European pediatric cancer center with an established management bundle.
Methods:In a prospective single-center observational cohort study conducted between 2007 and 2018, nasopharyngeal swabs for culture of MRSA were obtained from all inpatient admissions to the pediatric Oncology and HSCT wards. The primary endpoint of the study was the colonization rate over time. Secondary endpoints included antibiotic resistance patterns, clonal relationships tested by genotyping technologies, time burden of isolation measures, implementation and results of decolonization efforts. Occurrence of invasive MRSA infections was also assessed.
Results:MRSA-screening identified 34 colonized patients (median age: 11 years; range: 0-21 years) without trends over time. MRSA colonization was associated with the presence of central venous catheters (76 %), immigration background (32 %), antibacterial treatment in the previous 4 weeks (53 %), status post surgery (41 %) and previous allogeneic HSCT (32 %). There was no molecular evidence of patient-to-patient transmission. Standard MRSA eradication regimen led to a lasting eradication of the organism in 24 of 34 patients. There was a total of two patients with MRSA infection during the 12 years observation period and no mortality from MRSA.
Conclusions:Prospective monitoring revealed low rates of MRSA colonization and infection at our center. These low rates and the absence of patient-to-patient transmission support the effectiveness of the managment bundle of MRSA identification, isolation, and decolonization.
Keyword(s): MRSA, Children, Cancer