Session Type: ePosters
Session Title: ePosters
Authors(s): J. Weehuizen (1), S. Roeden (1), S. Hogewoning (2), W. Van Der Hoek (3), M. Bonten (4), A. Hoepelman (1), C. Bleeker-Rovers (5), P. Wever (6), J.J. Oosterheert (1)
Authors Affiliations(s): (1) Department of Internal Medicine and Infectious Diseases, University Medical Center Utrecht and Utrecht University, Netherlands, (2) Netherlands Comprehensive Cancer Organisation, Netherlands, (3) Centre for Infectious Disease Control, National Institute for Public Health and the Environment,, Netherlands, (4) Department of Medical Microbiology, University Medical Center Utrecht and Utrecht University, Netherlands, (5) Department of Internal Medicine and Infectious Diseases, Radboud University Medical Center and Radboud Expertise Center for Q fever, Netherlands, (6) Department of Medical Microbiology and Infection Control, Jeroen Bosch Hospital, Netherlands
Background:
A causative role of Coxiella burnetii in the pathogenesis of non-Hodgkin lymphoma (NHL) has been suggested, though supporting studies suffered from considerable risk of bias. We aimed to better quantify this association by assessing the risk of NHL after Q fever in the entire Dutch population over a 16 year period.
Methods:We performed a retrospective population-based linked analysis. The incidence of NHL in the entire Dutch population from 2002 until 2017 was studied and modeled with notified acute Q fever cases as determinant. The primary outcome measure was the adjusted relative risk for NHL after acute Q fever.
Results:Between January 2002 and December 2017, 266,050,745 person years were observed, with 68,485 persons diagnosed with NHL, reflecting a crude incidence rate of 25.7 cases per 100,000 person years. In total, 4,310 persons were diagnosed with acute Q fever, with a highest yearly incidence rate of 14.2 cases per 100,000 person years in 2009. The adjusted relative risk for NHL after acute Q fever was RR 1.01 (95% CI 0.97 – 1.06, p = 0.50), and 0.98 (95% CI 0.89 – 1.07, p = 0.60), 0.99 (95% CI 0.87 – 1.12, p = 0.85) and 0.98 (95% 0.88 – 1.08, p = 0.67) for subgroups of diffuse large cell B-cell lymphoma, follicular lymphoma, or B-cell chronic lymphatic leukemia, respectively. Modeling with lag times (1-4 years) did not change interpretation.
Although the Netherlands suffered the largest Q fever outbreak ever recorded, there is no evidence for association between acute Q fever and NHL.
Keyword(s): Q fever, Non-Hodgkin Lymphoma, OutbreakSession Type: ePosters
Session Title: ePosters
Authors(s): J. Weehuizen (1), S. Roeden (1), S. Hogewoning (2), W. Van Der Hoek (3), M. Bonten (4), A. Hoepelman (1), C. Bleeker-Rovers (5), P. Wever (6), J.J. Oosterheert (1)
Authors Affiliations(s): (1) Department of Internal Medicine and Infectious Diseases, University Medical Center Utrecht and Utrecht University, Netherlands, (2) Netherlands Comprehensive Cancer Organisation, Netherlands, (3) Centre for Infectious Disease Control, National Institute for Public Health and the Environment,, Netherlands, (4) Department of Medical Microbiology, University Medical Center Utrecht and Utrecht University, Netherlands, (5) Department of Internal Medicine and Infectious Diseases, Radboud University Medical Center and Radboud Expertise Center for Q fever, Netherlands, (6) Department of Medical Microbiology and Infection Control, Jeroen Bosch Hospital, Netherlands
Background:
A causative role of Coxiella burnetii in the pathogenesis of non-Hodgkin lymphoma (NHL) has been suggested, though supporting studies suffered from considerable risk of bias. We aimed to better quantify this association by assessing the risk of NHL after Q fever in the entire Dutch population over a 16 year period.
Methods:We performed a retrospective population-based linked analysis. The incidence of NHL in the entire Dutch population from 2002 until 2017 was studied and modeled with notified acute Q fever cases as determinant. The primary outcome measure was the adjusted relative risk for NHL after acute Q fever.
Results:Between January 2002 and December 2017, 266,050,745 person years were observed, with 68,485 persons diagnosed with NHL, reflecting a crude incidence rate of 25.7 cases per 100,000 person years. In total, 4,310 persons were diagnosed with acute Q fever, with a highest yearly incidence rate of 14.2 cases per 100,000 person years in 2009. The adjusted relative risk for NHL after acute Q fever was RR 1.01 (95% CI 0.97 – 1.06, p = 0.50), and 0.98 (95% CI 0.89 – 1.07, p = 0.60), 0.99 (95% CI 0.87 – 1.12, p = 0.85) and 0.98 (95% 0.88 – 1.08, p = 0.67) for subgroups of diffuse large cell B-cell lymphoma, follicular lymphoma, or B-cell chronic lymphatic leukemia, respectively. Modeling with lag times (1-4 years) did not change interpretation.
Although the Netherlands suffered the largest Q fever outbreak ever recorded, there is no evidence for association between acute Q fever and NHL.
Keyword(s): Q fever, Non-Hodgkin Lymphoma, Outbreak
UMC Utrecht - Department of Internal Medicine and Infectious Diseases
Session Type: ePosters
Session Title: ePosters
Authors(s): J. Weehuizen (1), S. Roeden (1), S. Hogewoning (2), W. Van Der Hoek (3), M. Bonten (4), A. Hoepelman (1), C. Bleeker-Rovers (5), P. Wever (6), J.J. Oosterheert (1)
Authors Affiliations(s): (1) Department of Internal Medicine and Infectious Diseases, University Medical Center Utrecht and Utrecht University, Netherlands, (2) Netherlands Comprehensive Cancer Organisation, Netherlands, (3) Centre for Infectious Disease Control, National Institute for Public Health and the Environment,, Netherlands, (4) Department of Medical Microbiology, University Medical Center Utrecht and Utrecht University, Netherlands, (5) Department of Internal Medicine and Infectious Diseases, Radboud University Medical Center and Radboud Expertise Center for Q fever, Netherlands, (6) Department of Medical Microbiology and Infection Control, Jeroen Bosch Hospital, Netherlands
Background:
A causative role of Coxiella burnetii in the pathogenesis of non-Hodgkin lymphoma (NHL) has been suggested, though supporting studies suffered from considerable risk of bias. We aimed to better quantify this association by assessing the risk of NHL after Q fever in the entire Dutch population over a 16 year period.
Methods:We performed a retrospective population-based linked analysis. The incidence of NHL in the entire Dutch population from 2002 until 2017 was studied and modeled with notified acute Q fever cases as determinant. The primary outcome measure was the adjusted relative risk for NHL after acute Q fever.
Results:Between January 2002 and December 2017, 266,050,745 person years were observed, with 68,485 persons diagnosed with NHL, reflecting a crude incidence rate of 25.7 cases per 100,000 person years. In total, 4,310 persons were diagnosed with acute Q fever, with a highest yearly incidence rate of 14.2 cases per 100,000 person years in 2009. The adjusted relative risk for NHL after acute Q fever was RR 1.01 (95% CI 0.97 – 1.06, p = 0.50), and 0.98 (95% CI 0.89 – 1.07, p = 0.60), 0.99 (95% CI 0.87 – 1.12, p = 0.85) and 0.98 (95% 0.88 – 1.08, p = 0.67) for subgroups of diffuse large cell B-cell lymphoma, follicular lymphoma, or B-cell chronic lymphatic leukemia, respectively. Modeling with lag times (1-4 years) did not change interpretation.
Although the Netherlands suffered the largest Q fever outbreak ever recorded, there is no evidence for association between acute Q fever and NHL.
Keyword(s): Q fever, Non-Hodgkin Lymphoma, OutbreakSession Type: ePosters
Session Title: ePosters
Authors(s): J. Weehuizen (1), S. Roeden (1), S. Hogewoning (2), W. Van Der Hoek (3), M. Bonten (4), A. Hoepelman (1), C. Bleeker-Rovers (5), P. Wever (6), J.J. Oosterheert (1)
Authors Affiliations(s): (1) Department of Internal Medicine and Infectious Diseases, University Medical Center Utrecht and Utrecht University, Netherlands, (2) Netherlands Comprehensive Cancer Organisation, Netherlands, (3) Centre for Infectious Disease Control, National Institute for Public Health and the Environment,, Netherlands, (4) Department of Medical Microbiology, University Medical Center Utrecht and Utrecht University, Netherlands, (5) Department of Internal Medicine and Infectious Diseases, Radboud University Medical Center and Radboud Expertise Center for Q fever, Netherlands, (6) Department of Medical Microbiology and Infection Control, Jeroen Bosch Hospital, Netherlands
Background:
A causative role of Coxiella burnetii in the pathogenesis of non-Hodgkin lymphoma (NHL) has been suggested, though supporting studies suffered from considerable risk of bias. We aimed to better quantify this association by assessing the risk of NHL after Q fever in the entire Dutch population over a 16 year period.
Methods:We performed a retrospective population-based linked analysis. The incidence of NHL in the entire Dutch population from 2002 until 2017 was studied and modeled with notified acute Q fever cases as determinant. The primary outcome measure was the adjusted relative risk for NHL after acute Q fever.
Results:Between January 2002 and December 2017, 266,050,745 person years were observed, with 68,485 persons diagnosed with NHL, reflecting a crude incidence rate of 25.7 cases per 100,000 person years. In total, 4,310 persons were diagnosed with acute Q fever, with a highest yearly incidence rate of 14.2 cases per 100,000 person years in 2009. The adjusted relative risk for NHL after acute Q fever was RR 1.01 (95% CI 0.97 – 1.06, p = 0.50), and 0.98 (95% CI 0.89 – 1.07, p = 0.60), 0.99 (95% CI 0.87 – 1.12, p = 0.85) and 0.98 (95% 0.88 – 1.08, p = 0.67) for subgroups of diffuse large cell B-cell lymphoma, follicular lymphoma, or B-cell chronic lymphatic leukemia, respectively. Modeling with lag times (1-4 years) did not change interpretation.
Although the Netherlands suffered the largest Q fever outbreak ever recorded, there is no evidence for association between acute Q fever and NHL.
Keyword(s): Q fever, Non-Hodgkin Lymphoma, Outbreak